Decisions that favor one’s own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that basolateral amygdala (BLA) neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic (PL) region of the prefrontal cortex mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives for decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.

Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice / D. Scheggia, F. LA GRECA, F. Maltese, G. Chiacchierini, M. Italia, C. Molent, F. Bernardi, M.G. Coccia, N. Carrano, E. Zianni, F. Gardoni, M.M.G. Diluca, F. Papaleo. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 25:11(2022 Oct 24), pp. 1505-1518. [10.1038/s41593-022-01179-2]

Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice

D. Scheggia
Primo
;
F. LA GRECA
Secondo
;
M. Italia;M.G. Coccia;E. Zianni;F. Gardoni;M.M.G. Diluca
Penultimo
;
2022

Abstract

Decisions that favor one’s own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that basolateral amygdala (BLA) neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic (PL) region of the prefrontal cortex mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives for decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.
Settore BIO/14 - Farmacologia
MIS18LCAFF_01 - Dysbindin-antipsychotics psychophamarcogenetics: a mouse-human translational study towards personalized healthcare in bipolar disorders - CAFFINO, LUCIA - MIS - Bandi Ministero Salute - 2018
CAR_RIC20DSCHE_01 - Synapse-to-nucleus signalling in Alzheimer's disease - SCHEGGIA, DIEGO - CAR_RIC - Bandi Fondazione Cariplo - 2020
https://doi.org/10.1038/s41593-022-01179-2
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/945170
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