Aggregation-induced emissive materials are gaining particular attention in the last decades due to their wide application in different fields, from optical devices to biomedicine. In this work, compounds having these kinds of properties, composed of tetraphenylethylene scaffold combined with fatty acids of different lengths, were synthesized and characterized. These molecules were found able to self-assemble into different supramolecular emissive structures depending on the chemical composition and water content. Furthermore, they were used as N-terminus capping agents in the development of peptide-based materials. The functionalization of a 5-mer laminin-derived peptide led to the obtainment of luminescent fibrillary materials that were not cytotoxic and were able to form supramolecular gels in aqueous environment.

Fatty Acids/Tetraphenylethylene Conjugates: Hybrid AIEgens for the Preparation of Peptide-Based Supramolecular Gels / E. Impresari, A. Bossi, E.M. Lumina, M.A. Ortenzi, J.M. Kothuis, G. Cappelletti, D. Maggioni, M.S. Christodoulou, R. Bucci, S. Pellegrino. - In: FRONTIERS IN CHEMISTRY. - ISSN 2296-2646. - 10:(2022 Aug 08), pp. 927563.1-927563.14. [10.3389/fchem.2022.927563]

Fatty Acids/Tetraphenylethylene Conjugates: Hybrid AIEgens for the Preparation of Peptide-Based Supramolecular Gels

E. Impresari
Primo
;
M.A. Ortenzi;J.M. Kothuis;G. Cappelletti;D. Maggioni;M.S. Christodoulou;R. Bucci
Penultimo
;
S. Pellegrino
Ultimo
2022

Abstract

Aggregation-induced emissive materials are gaining particular attention in the last decades due to their wide application in different fields, from optical devices to biomedicine. In this work, compounds having these kinds of properties, composed of tetraphenylethylene scaffold combined with fatty acids of different lengths, were synthesized and characterized. These molecules were found able to self-assemble into different supramolecular emissive structures depending on the chemical composition and water content. Furthermore, they were used as N-terminus capping agents in the development of peptide-based materials. The functionalization of a 5-mer laminin-derived peptide led to the obtainment of luminescent fibrillary materials that were not cytotoxic and were able to form supramolecular gels in aqueous environment.
aggregation-induced emission (AIE); luminescent materials; peptide materials; self-assembly; supramolecular gel;
Settore CHIM/06 - Chimica Organica
   Piano Sviluppo Unimi - Linea 3 - Bando SOE 2020 - Progetto ICEFree
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   UNIVERSITA' DEGLI STUDI DI MILANO
8-ago-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/945088
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