Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystem disorder; cardiac involvement may include eosinophilic myocarditis. A 67-year-old woman presented with 1-week history of dyspnoea and orthopnoea. She had a history of adult-onset asthma and peripheral eosinophilia. The investigations showed T-wave inversion on lateral leads, peripheral eosinophilia, elevated troponin and BNP values, and severe biventricular systolic dysfunction with diffuse hypokinesia and apical akinesia. Computed tomography excluded coronary disease and showed bilateral basal ground-glass opacities, air-space consolidation, and bilateral reticular-nodular pattern. Cardiac magnetic resonance findings were compatible with active myocardial inflammation. An endomyocardial biopsy (EMB) confirmed the diagnosis of eosinophilic myocarditis, and a therapy with oral corticosteroids and heart failure medications was started.

What's behind your eosinophilic myocarditis? A case of Churg–Strauss syndrome diagnosed during acute heart failure / N. Amelotti, M. Mapelli, M. Guglielmo, M. Inês Fiuza Branco Pires, J.S. Campodonico, B. Majocchi, V. Ribatti, G. Vettor, A. Baggiano, V. Catto, C. Basso, G. Pontone, P. Agostoni. - In: ESC HEART FAILURE. - ISSN 2055-5822. - (2022 Oct 19). [Epub ahead of print] [10.1002/ehf2.14172]

What's behind your eosinophilic myocarditis? A case of Churg–Strauss syndrome diagnosed during acute heart failure

N. Amelotti
Co-primo
;
M. Mapelli
Co-primo
;
J.S. Campodonico;A. Baggiano;P. Agostoni
Ultimo
2022

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystem disorder; cardiac involvement may include eosinophilic myocarditis. A 67-year-old woman presented with 1-week history of dyspnoea and orthopnoea. She had a history of adult-onset asthma and peripheral eosinophilia. The investigations showed T-wave inversion on lateral leads, peripheral eosinophilia, elevated troponin and BNP values, and severe biventricular systolic dysfunction with diffuse hypokinesia and apical akinesia. Computed tomography excluded coronary disease and showed bilateral basal ground-glass opacities, air-space consolidation, and bilateral reticular-nodular pattern. Cardiac magnetic resonance findings were compatible with active myocardial inflammation. An endomyocardial biopsy (EMB) confirmed the diagnosis of eosinophilic myocarditis, and a therapy with oral corticosteroids and heart failure medications was started.
Eosinophilic granulomatosis with polyangiitis (Churg–Strauss); Eosinophilic myocarditis; Heart failure; Endomyocardial biopsy; Cardiac magnetic resonance
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
19-ott-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/943607
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