Objectives To evaluate retention, efficacy, and safety of subcutaneous (SC) abatacept over 2 years in patients with moderateto-severe RA in the Abatacept SubCutaneOus in Routine clinical practicE (ASCORE) study.Methods Patients with RA who initiated SC abatacept 125 mg once weekly were enrolled in the international, observational, prospective multicentre ASCORE study into biologic-naive or >= 1 prior biologic failure cohorts. Primary endpoint: abatacept retention rate at 2 years. Secondary endpoints: proportion of patients with good/moderate EULAR response rates based on DAS28 (ESR), low disease activity and/or remission according to DAS28 (ESR; <= 3.2/ <= 2.6), SDAI (<= 11/ <= 3.3), CDAI (<= 10/ <= 2.8), and Boolean criteria. Retention rate by baseline serostatus was evaluated post hoc.Results Overall, 47% of patients remained on abatacept for 2 years, irrespective of treatment line. Higher abatacept retention rates were associated with lower prior biologic exposure. Generally, clinical outcomes showed that the proportion of patients with low disease activity/remission was higher in biologic-naive patients (vs biologic-failure) and similar in those with 1 and >= 2 prior biologic failures. In patients on treatment at 2 years, good/moderate EULAR response rates of similar to 80% were consistently noted irrespective of prior biologic exposure. Across treatment lines, retention was greater in patients with seropositive (vs seronegative) RA. Patients with rheumatoid factor/anti-citrullinated protein antibody single-positive RA who were bio-naive had higher retention than patients who were bio-experienced.Conclusions In the ASCORE study, SC abatacept retention was 47% at 2 years with good clinical outcomes and was well-tolerated in the real-world setting. Abatacept retention and clinical response rates were higher in patients who received abatacept as an earlier- versus later-line biologic drug treatment and in those with seropositive RA.

Retention of subcutaneous abatacept for the treatment of rheumatoid arthritis: real-world results from the ASCORE study: an international 2-year observational studyIn: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - 41:8(2022 Aug), pp. 2361-2373. [10.1007/s10067-022-06176-1]

Retention of subcutaneous abatacept for the treatment of rheumatoid arthritis: real-world results from the ASCORE study: an international 2-year observational study

R. Caporali;
2022

Abstract

Objectives To evaluate retention, efficacy, and safety of subcutaneous (SC) abatacept over 2 years in patients with moderateto-severe RA in the Abatacept SubCutaneOus in Routine clinical practicE (ASCORE) study.Methods Patients with RA who initiated SC abatacept 125 mg once weekly were enrolled in the international, observational, prospective multicentre ASCORE study into biologic-naive or >= 1 prior biologic failure cohorts. Primary endpoint: abatacept retention rate at 2 years. Secondary endpoints: proportion of patients with good/moderate EULAR response rates based on DAS28 (ESR), low disease activity and/or remission according to DAS28 (ESR; <= 3.2/ <= 2.6), SDAI (<= 11/ <= 3.3), CDAI (<= 10/ <= 2.8), and Boolean criteria. Retention rate by baseline serostatus was evaluated post hoc.Results Overall, 47% of patients remained on abatacept for 2 years, irrespective of treatment line. Higher abatacept retention rates were associated with lower prior biologic exposure. Generally, clinical outcomes showed that the proportion of patients with low disease activity/remission was higher in biologic-naive patients (vs biologic-failure) and similar in those with 1 and >= 2 prior biologic failures. In patients on treatment at 2 years, good/moderate EULAR response rates of similar to 80% were consistently noted irrespective of prior biologic exposure. Across treatment lines, retention was greater in patients with seropositive (vs seronegative) RA. Patients with rheumatoid factor/anti-citrullinated protein antibody single-positive RA who were bio-naive had higher retention than patients who were bio-experienced.Conclusions In the ASCORE study, SC abatacept retention was 47% at 2 years with good clinical outcomes and was well-tolerated in the real-world setting. Abatacept retention and clinical response rates were higher in patients who received abatacept as an earlier- versus later-line biologic drug treatment and in those with seropositive RA.
Abatacept; Biological therapy; Retention; Rheumatoid arthritis; Abatacept; Humans; Prospective Studies; Treatment Outcome; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products
Settore MED/16 - Reumatologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/943107
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