Sentinel lymph node biopsy (SLNB) is an accepted veterinary surgical procedure given the impact of early detection of nodal metastases on staging of several canine malignancies. This study aims at reporting the incidence and risk factors for surgical complications of SLNB in tumour-bearing dogs. A total of 113 client-owned dogs that underwent tumour excision and SLNB guided by gamma-probing and blue dye were retrospectively enrolled. Recorded variables included: signalment, location and number of extirpated lymphocenters and nodes, time for SLNB, histopathological status of excised nodes. Incidence of SLNB complications was calculated. They were classified as minor and major based on severity and required treatment, and as short-term (0-30 days) and long-term (31-90 days). Univariate analysis with generalized linear model with binomial error estimated the association between variables and incidence of SLNB complications. Significance was set at 5%. Median overall time for SLNB was 25 min. Surgeons excised one node in 38% of dogs and multiple nodes in 62% of cases, belonging to one (62%) or multiple (38%) lymphocenters. Metastases were detected in 45% of nodes. No intraoperative complications occurred. The overall incidence of postoperative complications of SLNB was 21,24%, the majority of which (91.67%) were minor. Only increasing dogs' weight was associated with an increased incidence of SLNB complications (p = .00976). Sentinel lymphadenectomy was associated with a relatively low incidence of complications, most of which were self-limiting. The low morbidity and previously reported impact on staging of SLNB justify its implementation to collect data for prognostic studies.

Surgical complications following sentinel lymph node biopsy guided by γ‐probe and methylene blue in 113 tumour‐bearing dogs / L.E. Chiti, M. Gariboldi Elisa, R. Ferrari, E. Luconi, P. Boracchi, D. DE ZANI, D. Zani, M. Manfredi, C. Spediacci, V. Grieco, C. Giudice, C. Recordati, F. Ferrari, D. Stefanello. - In: VETERINARY AND COMPARATIVE ONCOLOGY. - ISSN 1476-5829. - (2022). [Epub ahead of print] [10.1111/vco.12861]

Surgical complications following sentinel lymph node biopsy guided by γ‐probe and methylene blue in 113 tumour‐bearing dogs

L.E. Chiti
Primo
;
R. Ferrari
;
E. Luconi;P. Boracchi;D. DE ZANI;D. Zani;M. Manfredi;C. Spediacci;V. Grieco;C. Giudice;C. Recordati;F. Ferrari;D. Stefanello
Ultimo
2022

Abstract

Sentinel lymph node biopsy (SLNB) is an accepted veterinary surgical procedure given the impact of early detection of nodal metastases on staging of several canine malignancies. This study aims at reporting the incidence and risk factors for surgical complications of SLNB in tumour-bearing dogs. A total of 113 client-owned dogs that underwent tumour excision and SLNB guided by gamma-probing and blue dye were retrospectively enrolled. Recorded variables included: signalment, location and number of extirpated lymphocenters and nodes, time for SLNB, histopathological status of excised nodes. Incidence of SLNB complications was calculated. They were classified as minor and major based on severity and required treatment, and as short-term (0-30 days) and long-term (31-90 days). Univariate analysis with generalized linear model with binomial error estimated the association between variables and incidence of SLNB complications. Significance was set at 5%. Median overall time for SLNB was 25 min. Surgeons excised one node in 38% of dogs and multiple nodes in 62% of cases, belonging to one (62%) or multiple (38%) lymphocenters. Metastases were detected in 45% of nodes. No intraoperative complications occurred. The overall incidence of postoperative complications of SLNB was 21,24%, the majority of which (91.67%) were minor. Only increasing dogs' weight was associated with an increased incidence of SLNB complications (p = .00976). Sentinel lymphadenectomy was associated with a relatively low incidence of complications, most of which were self-limiting. The low morbidity and previously reported impact on staging of SLNB justify its implementation to collect data for prognostic studies.
canine; complications; lymphadenectomy; sentinel lymph node
Settore VET/09 - Clinica Chirurgica Veterinaria
30-set-2022
http://doi.org/10.1111/vco.12861
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/942226
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