To assess whether either duration and magnitude of ductal shunt or medical treatment for patent ductus arteriosus (PDA) are related to spontaneous intestinal perforation (SIP). Study design: Clinical charts of infants <29 weeks’ gestation born from 2006 to 2018 were reviewed. Echocardiographic examinations were evaluated according to McNamara and Sehgal’s staging system. Results: A higher percentage of patients with SIP had a hemodynamically significant PDA (HSPDA) and was treated with either NSAIDs or paracetamol (79% vs 53% and 81% vs 54%, respectively). Among non-treated patients, we found a 1.32 increase in the odds of SIP per day of persistence of HSPDA. In the cohort of patients treated despite the absence of HSPDA, we found a 2.35 increase in the odds of SIP per dose of drug administered. Conclusion: Both treating a non-HSPDA and leaving a HSPDA to its natural history seem to be associated with SIP.

Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants / A. Mayer, G. Francescato, N. Pesenti, F. Schena, F. Mosca. - In: JOURNAL OF PERINATOLOGY. - ISSN 0743-8346. - (2022 May 19), pp. 1-5. [Epub ahead of print] [10.1038/s41372-022-01403-8]

Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants

A. Mayer;G. Francescato
;
F. Schena;F. Mosca
2022

Abstract

To assess whether either duration and magnitude of ductal shunt or medical treatment for patent ductus arteriosus (PDA) are related to spontaneous intestinal perforation (SIP). Study design: Clinical charts of infants <29 weeks’ gestation born from 2006 to 2018 were reviewed. Echocardiographic examinations were evaluated according to McNamara and Sehgal’s staging system. Results: A higher percentage of patients with SIP had a hemodynamically significant PDA (HSPDA) and was treated with either NSAIDs or paracetamol (79% vs 53% and 81% vs 54%, respectively). Among non-treated patients, we found a 1.32 increase in the odds of SIP per day of persistence of HSPDA. In the cohort of patients treated despite the absence of HSPDA, we found a 2.35 increase in the odds of SIP per dose of drug administered. Conclusion: Both treating a non-HSPDA and leaving a HSPDA to its natural history seem to be associated with SIP.
Settore MED/38 - Pediatria Generale e Specialistica
Article (author)
File in questo prodotto:
File Dimensione Formato  
mayer2022.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 427.27 kB
Formato Adobe PDF
427.27 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/940495
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 0
social impact