Paroxetine, a selective serotonin reuptake inhibitor (SSRI), is prescribed to treat psychiatric disorders, although an off-label SSRI use is also for functional gastrointestinal disorders. The mutual correlation between serotonin and peripheral sex steroids has been reported, however little attention to sex steroids synthesized by gut, has been given so far. Indeed, whether SSRIs, may also influence the gut steroid production, immediately after treatment and/or after suspension, is sti l l unclear. The finding that gut possesses steroidogenic capability is of particular relevance, also for the existence of the gut-microbiota-brain axis, where gut microbiota represents a key orchestrator. On this basis, adult male rats were treated daily for two weeks with paroxetine or vehicle and, 24 h after treatment and at 1 month of withdrawal , steroid environment and gut microbiota were evaluated. Results obtained reveal that paroxetine significantly affects steroid levels, only in the colon but not in plasma. In particular, steroid modifications observed immediately after treatment are not overlap with those detected at withdrawal. Additionally, paroxetine treatment and its withdrawal impact gut microbiota populations differ-ently. Altogether, these results suggest a biphasic effect of the drug treatment in the gut both on steroidogenesis and microbiota.

Paroxetine effects in adult male rat colon: Focus on gut steroidogenesis and microbiota / S. Diviccaro, S. Giatti, L. Cioffi, E. Falvo, R. Piazza, D. Caruso, R. Melcangi. - In: PSYCHONEUROENDOCRINOLOGY. - ISSN 0306-4530. - 143:(2022 Sep), pp. 105828.1-105828.12. [10.1016/j.psyneuen.2022.105828]

Paroxetine effects in adult male rat colon: Focus on gut steroidogenesis and microbiota

S. Diviccaro
Primo
;
S. Giatti
Secondo
;
L. Cioffi;E. Falvo;D. Caruso
Penultimo
;
R. Melcangi
Ultimo
2022

Abstract

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), is prescribed to treat psychiatric disorders, although an off-label SSRI use is also for functional gastrointestinal disorders. The mutual correlation between serotonin and peripheral sex steroids has been reported, however little attention to sex steroids synthesized by gut, has been given so far. Indeed, whether SSRIs, may also influence the gut steroid production, immediately after treatment and/or after suspension, is sti l l unclear. The finding that gut possesses steroidogenic capability is of particular relevance, also for the existence of the gut-microbiota-brain axis, where gut microbiota represents a key orchestrator. On this basis, adult male rats were treated daily for two weeks with paroxetine or vehicle and, 24 h after treatment and at 1 month of withdrawal , steroid environment and gut microbiota were evaluated. Results obtained reveal that paroxetine significantly affects steroid levels, only in the colon but not in plasma. In particular, steroid modifications observed immediately after treatment are not overlap with those detected at withdrawal. Additionally, paroxetine treatment and its withdrawal impact gut microbiota populations differ-ently. Altogether, these results suggest a biphasic effect of the drug treatment in the gut both on steroidogenesis and microbiota.
Actinobacteria; Cyanobacteria; Firmicutes; Pregnenolone; SSRI; Sex steroids; Animals; Colon; Humans; Male; Rats; Serotonin Uptake Inhibitors; Steroids; Microbiota; Paroxetine;
Settore MED/13 - Endocrinologia
Settore BIO/10 - Biochimica
PON18MRIVA_01 - Medicina personalizzata per strategie innovative in malattie neuro-psichiatriche e vascolari (PerMedNet) - RIVA, MARCO ANDREA - PON PNR 2015-2020 - 2018
9-giu-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/939792
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