Since the start of SARS-CoV-2 pandemic, children aged <= 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections' frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged <= 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.

Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation / C. Alteri, R. Scutari, V. Costabile, L. Colagrossi, K. Yu La Rosa, E. Agolini, V. Lanari, S. Chiurchiù, L. Romani, A.H. Markowich, P. Bernaschi, C. Russo, A. Novelli, S. Bernardi, A. Campana, A. Villani, C.F. Perno. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 12:1(2022 Jun 17), pp. 10194.1-10194.12. [10.1038/s41598-022-14426-0]

Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation

C. Alteri
Primo
;
R. Scutari
Secondo
;
2022

Abstract

Since the start of SARS-CoV-2 pandemic, children aged <= 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections' frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged <= 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.
Child; Humans; Pandemics; Viral Load; COVID-19; SARS-CoV-2;
Settore MED/07 - Microbiologia e Microbiologia Clinica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/939479
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