Angiogenesis, the growth of new blood vessels from pre-existing ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining and analysis.

The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis / A. Fantin, C. Ruhrberg (METHODS IN MOLECULAR BIOLOGY). - In: VEGF Signaling : Methods and Protocols / [a cura di] L. R. Fiedler, C. Pellet-Many. - Prima edizione. - [s.l] : Humana Press : Springer, 2022. - ISBN 978-1-0716-2217-9. - pp. 275-287 [10.1007/978-1-0716-2217-9_20]

The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis

A. Fantin
Primo
;
2022

Abstract

Angiogenesis, the growth of new blood vessels from pre-existing ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining and analysis.
Angiogenesis; Hindbrain; Retina;
Settore BIO/09 - Fisiologia
Settore BIO/13 - Biologia Applicata
Settore BIO/17 - Istologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/939171
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