Lipid metabolism impacts immune cell differentiation, activation, and functions, modulating inflammatory mediators, energy homeostasis, and cell membrane composition. Despite preclinical evidence, data in humans lack concerning tumors and immunotherapy (IO). We aimed at investigating the correlations between circulating lipids and the outcome of non-small cell lung cancer (NSCLC) patients treated with IO.

Circulating Fatty Acid Profile as a Biomarker for Immunotherapy in Advanced Non-Small Cell Lung Cancer / G. Galli, P.A. Corsetto, C. Proto, G. Lo Russo, M. Ganzinelli, E. Rulli, L. Legramandi, D. Morelli, R. Ferrara, A. Prelaj, D. Signorelli, A. De Toma, M. Brambilla, M. Occhipinti, S. Manglaviti, M. Boeri, A. Martinetti, A. Vingiani, M.P. Colombo, A.M. Rizzo, V. Torri, F. de Braud, S. Sangaletti, A. Sica, M.C. Garassino. - In: CLINICAL LUNG CANCER. - ISSN 1525-7304. - (2022), pp. 1-11. [Epub ahead of print] [10.1016/j.cllc.2022.07.010]

Circulating Fatty Acid Profile as a Biomarker for Immunotherapy in Advanced Non-Small Cell Lung Cancer

G. Galli
Co-primo
;
P.A. Corsetto
Co-primo
;
M. Brambilla;M. Occhipinti;S. Manglaviti;A. Vingiani;A.M. Rizzo;F. de Braud;
2022

Abstract

Lipid metabolism impacts immune cell differentiation, activation, and functions, modulating inflammatory mediators, energy homeostasis, and cell membrane composition. Despite preclinical evidence, data in humans lack concerning tumors and immunotherapy (IO). We aimed at investigating the correlations between circulating lipids and the outcome of non-small cell lung cancer (NSCLC) patients treated with IO.
Fatty acids; Immunotherapy; Lipid metabolism; Membrane fluidity; Non-small cell lung cancer
Settore MED/06 - Oncologia Medica
Settore BIO/10 - Biochimica
21-lug-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/938786
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