The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) published evidence-based recommendations for cancer prevention focusing on body weight, physical activity and diet. Our aim is to evaluate whether adherence to the WCRF/AICR recommendations could reduce endometrial cancer risk. We used data from a multicentric, Italian hospital-based case-control study (1992-2006) including 454 endometrial cancer cases and 908 age-matched controls. Adherence to the WCRF/AICR recommendations was measured using a score (range: 0-7) based on seven components: body mass index (BMI), physical activity and five dietary items; higher scores indicated higher adherence. Odds ratios (ORs) were estimated by multiple (adjusted) conditional logistic regression models including terms for major confounders and energy intake. Adherence to the WCRF/AICR recommendations was inversely related with endometrial cancer risk (OR=0.42, 95% confidence interval (CI): 0.30-0.61 for the highest compared to the lowest score quartile), with a significant trend of decreasing risk with increasing adherence. An inverse association was also observed for a score including only dietary recommendations (OR=0.67, 95% CI: 0.46-0.96 for the highest compared to the lowest score tertile). In stratified analyses, the association was stronger among women with a normal weight, those who were older, and consequently those in postmenopause, and those with ≥2 children. In conclusion, high adherence to the WCRF/AICR recommendations has a favorable role in endometrial cancer risk, which is not fully explained by body weight.

Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and endometrial cancer risk: a multicentric case-control study / G. Esposito, F. Turati, D. Serraino, A. Crispo, E. Negri, F. Parazzini, C. La Vecchia. - In: BRITISH JOURNAL OF NUTRITION. - ISSN 1475-2662. - (2022). [Epub ahead of print] [10.1017/S0007114522002872]

Adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations and endometrial cancer risk: a multicentric case-control study

G. Esposito
Primo
;
F. Turati
Secondo
;
E. Negri;F. Parazzini
Penultimo
;
C. La Vecchia
Ultimo
2022

Abstract

The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) published evidence-based recommendations for cancer prevention focusing on body weight, physical activity and diet. Our aim is to evaluate whether adherence to the WCRF/AICR recommendations could reduce endometrial cancer risk. We used data from a multicentric, Italian hospital-based case-control study (1992-2006) including 454 endometrial cancer cases and 908 age-matched controls. Adherence to the WCRF/AICR recommendations was measured using a score (range: 0-7) based on seven components: body mass index (BMI), physical activity and five dietary items; higher scores indicated higher adherence. Odds ratios (ORs) were estimated by multiple (adjusted) conditional logistic regression models including terms for major confounders and energy intake. Adherence to the WCRF/AICR recommendations was inversely related with endometrial cancer risk (OR=0.42, 95% confidence interval (CI): 0.30-0.61 for the highest compared to the lowest score quartile), with a significant trend of decreasing risk with increasing adherence. An inverse association was also observed for a score including only dietary recommendations (OR=0.67, 95% CI: 0.46-0.96 for the highest compared to the lowest score tertile). In stratified analyses, the association was stronger among women with a normal weight, those who were older, and consequently those in postmenopause, and those with ≥2 children. In conclusion, high adherence to the WCRF/AICR recommendations has a favorable role in endometrial cancer risk, which is not fully explained by body weight.
Case-control study; Endometrial cancer; WCRF; diet; lifestyle; prevention
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
Settore MED/42 - Igiene Generale e Applicata
12-set-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/937647
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