Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. However, some problems, related to short in situ residence time, reduce their feasible clinical use. Thus, in order to improve the effective applicability of these materials, we studied how P407 thermogels are affected by the pH and by the inclusion of different hydrophilic polymers, used as excipients for increasing the gel stiffness. For this scope, a complete chemical-physical characterization of the synthesized gels is provided, in terms of determination of sol-gel transition temperature, viscosity and erosion degree. The data are correlated according to a statistical multivariate approach based on Principal Component Analysis and their mucoadhesion properties are also tested by Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, we studied how the different P407 formulations are able to influence the release pathway of two antibacterial drugs (i.e., chlorhexidine digluconate and doxycycline hyclate) largely used in oral diseases.

Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties / E. Brambilla, S. Locarno, S. Gallo, F. Orsini, C. Pini, M. Farronato, D.V. Thomaz, C. Lenardi, M. Piazzoni, G. Tartaglia. - In: POLYMERS. - ISSN 2073-4360. - 14:17(2022 Sep 01), pp. 3624.1-3624.16. [10.3390/polym14173624]

Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties

E. Brambilla
Co-primo
Formal Analysis
;
S. Locarno
Co-primo
Formal Analysis
;
S. Gallo
Formal Analysis
;
F. Orsini
Investigation
;
M. Farronato
Visualization
;
C. Lenardi
Supervision
;
M. Piazzoni
Penultimo
Visualization
;
G. Tartaglia
Ultimo
Supervision
2022-09-01

Abstract

Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. However, some problems, related to short in situ residence time, reduce their feasible clinical use. Thus, in order to improve the effective applicability of these materials, we studied how P407 thermogels are affected by the pH and by the inclusion of different hydrophilic polymers, used as excipients for increasing the gel stiffness. For this scope, a complete chemical-physical characterization of the synthesized gels is provided, in terms of determination of sol-gel transition temperature, viscosity and erosion degree. The data are correlated according to a statistical multivariate approach based on Principal Component Analysis and their mucoadhesion properties are also tested by Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, we studied how the different P407 formulations are able to influence the release pathway of two antibacterial drugs (i.e., chlorhexidine digluconate and doxycycline hyclate) largely used in oral diseases.
poloxamer 407; thermogelling hydrogel; hydrophilic polymers; drug delivery system; chlorhexidine digluconate; doxycycline hyclate
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore CHIM/06 - Chimica Organica
Settore MED/28 - Malattie Odontostomatologiche
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/02 - Chimica Fisica
29-ago-2022
https://www.mdpi.com/2073-4360/14/17/3624
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/937293
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