Epidemiological studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer (EC), the most common gynecological malignancy in developed countries. Furthermore, coffee consumption may lower circulating levels of estrogen and insulin, hormones implicated in endometrial carcinogenesis. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. Based on available meta-analyses, the World Cancer Research Fund concluded that consumption of coffee probably protects against EC.
Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2) / M. Crous-Bou, M. Du, M.J. Gunter, V.W. Setiawan, L.J. Schouten, X. Shu, N. Wentzensen, K.A. Bertrand, L.S. Cook, C.M. Friedenreich, S.M. Gapstur, M.T. Goodman, T.I. Ibiebele, C. La Vecchia, F. Levi, L.M. Liao, E. Negri, S.E. Mccann, K. O'Connell, J.R. Palmer, A.V. Patel, J. Ponte, P. Reynolds, C. Sacerdote, R. Sinha, A.B. Spurdle, B. Trabert, P.A. van den Brandt, P.M. Webb, S. Petruzella, S.H. Olson, I. De Vivo. - In: THE AMERICAN JOURNAL OF CLINICAL NUTRITION. - ISSN 0002-9165. - 116:5(2022 Nov 05), pp. 1219-1228. [10.1093/ajcn/nqac229]
Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2)
C. La Vecchia;E. Negri;
2022
Abstract
Epidemiological studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer (EC), the most common gynecological malignancy in developed countries. Furthermore, coffee consumption may lower circulating levels of estrogen and insulin, hormones implicated in endometrial carcinogenesis. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. Based on available meta-analyses, the World Cancer Research Fund concluded that consumption of coffee probably protects against EC.
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Cofeee endom E2C2 Crous_Bou_Am_J_Clin_Nutr.pdf
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