In this work, the isolation step in the linear ion trap was performed using different "q values" conditions at a low collision-induced dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and low voltage ionization near the q value = 0.778 and with a CID energy of 10%. This effect was evaluated with low-molecular-mass compounds (skatole and arginine). The proposed optimization yielded a superior instrument performance without adding technological complexity to mass spectrometry analyses.

q value and parent energy optimization using a low-voltage ionization approach increases resolution in linear ion trap mass spectrometry / S. Madama, E. Falletta, A.M. Malvandi, K. Arzoni, C. Brogna, M. Varelli, M. Bertelli, M. Conti, M. Larini, F. Guidugli, P. Traldi, S. Cristoni. - In: JOURNAL OF MASS SPECTROMETRY. - ISSN 1096-9888. - 57:8(2022 Aug), pp. e4876.1-e4876.7. [10.1002/jms.4876]

q value and parent energy optimization using a low-voltage ionization approach increases resolution in linear ion trap mass spectrometry

E. Falletta
Secondo
;
A.M. Malvandi;M. Conti;S. Cristoni
Ultimo
2022

Abstract

In this work, the isolation step in the linear ion trap was performed using different "q values" conditions at a low collision-induced dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and low voltage ionization near the q value = 0.778 and with a CID energy of 10%. This effect was evaluated with low-molecular-mass compounds (skatole and arginine). The proposed optimization yielded a superior instrument performance without adding technological complexity to mass spectrometry analyses.
MS accuracy; MS resolution; ion trap; low voltage ionization; metabolites; q value; Gas Chromatography-Mass Spectrometry; Spectrometry, Mass, Electrospray Ionization
Settore CHIM/04 - Chimica Industriale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/936352
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