We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.
|Titolo:||Programmed cell death of myelin basic protein specific T lymphocytes is reduced in patients with acute multiple sclerosis|
|Autori interni:||DELLA BELLA, SILVIA ANGELA MARIA|
TRABATTONI, DARIA LUCIA
FASANO, FRANCESCA ROMANA
CLERICI, MARIO SALVATORE (Penultimo)
FERRANTE, PASQUALE (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||10.1016/j.jneuroim.2005.05.010|
|Appare nelle tipologie:||01 - Articolo su periodico|
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