We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.
Programmed cell death of myelin basic protein specific T lymphocytes is reduced in patients with acute multiple sclerosis / M. Saresella, I. Marventano, L. Speciale, S. Ruzzante, D. Trabattoni, S. Della Bella, M. Filippi, F. Fasano, R. Cavarretta, D. Caputo, M. Clerici, P. Ferrante. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 166:1-2(2005), pp. 173-179. [10.1016/j.jneuroim.2005.05.010]
Programmed cell death of myelin basic protein specific T lymphocytes is reduced in patients with acute multiple sclerosis
D. Trabattoni;S. Della Bella;F.R. Fasano;M. ClericiPenultimo
;P. FerranteUltimo
2005
Abstract
We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.Pubblicazioni consigliate
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