Recent evidence highlights patients' sex relevance in antitumor immune response through a complex interaction-among hormones, genes, behaviors, and the microbiome-that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.

Sex and cancer immunotherapy: Current understanding and challenges / L. Pala, T. De Pas, C. Catania, G. Giaccone, A. Mantovani, S. Minucci, G. Viale, R.D. Gelber, F. Conforti. - In: CANCER CELL. - ISSN 1535-6108. - 40:7(2022), pp. 695-700. [10.1016/j.ccell.2022.06.005]

Sex and cancer immunotherapy: Current understanding and challenges

S. Minucci;G. Viale;F. Conforti
Ultimo
2022

Abstract

Recent evidence highlights patients' sex relevance in antitumor immune response through a complex interaction-among hormones, genes, behaviors, and the microbiome-that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.
Humans; Immunity; Immunotherapy; Neoplasms
Settore MED/04 - Patologia Generale
Settore MED/08 - Anatomia Patologica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/936227
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