Chronic Kidney Disease (CKD) is characterized by a progressive and irreversible loss of kidney function which gradually leads to end-stage kidney disease (ESKD). Virtually all the organs are damaged by the toxicity of uremic compounds. The lungs may be affected and the impaired pulmonary function may be the direct result of fluid retention and metabolic, endocrine and cardiovascular alterations, as well as systemic activation of the inflammation. An increased prevalence in sleep disorders (SD) is also reported in patients with CKD, leading to a further negative impact on overall health and quality of life. While these complex relationships are well documented in the adult population, these aspects remain relatively little investigated in children. The aim of this review is to provide a brief overview of the pathophysiology between lung and kidney and to summarize how CKD may affect respiratory function and sleep in children.

Respiratory complications and sleep disorders in children with chronic kidney disease: A correlation often underestimated / M. Lelii, L. Senatore, F. Paglialonga, S. Consolo, G. Montini, A. Rocchi, P. Marchisio, M.F. Patria. - In: PAEDIATRIC RESPIRATORY REVIEWS. - ISSN 1526-0542. - (2022), pp. 1-7. [Epub ahead of print] [10.1016/j.prrv.2021.12.003]

Respiratory complications and sleep disorders in children with chronic kidney disease: A correlation often underestimated

G. Montini;P. Marchisio
Penultimo
;
2022

Abstract

Chronic Kidney Disease (CKD) is characterized by a progressive and irreversible loss of kidney function which gradually leads to end-stage kidney disease (ESKD). Virtually all the organs are damaged by the toxicity of uremic compounds. The lungs may be affected and the impaired pulmonary function may be the direct result of fluid retention and metabolic, endocrine and cardiovascular alterations, as well as systemic activation of the inflammation. An increased prevalence in sleep disorders (SD) is also reported in patients with CKD, leading to a further negative impact on overall health and quality of life. While these complex relationships are well documented in the adult population, these aspects remain relatively little investigated in children. The aim of this review is to provide a brief overview of the pathophysiology between lung and kidney and to summarize how CKD may affect respiratory function and sleep in children.
Central apnoea; Chronic kidney disease; End-stage renal disease; Hypoventilation; Lung function; Quality of life; Sleep-disordered breathing
Settore MED/38 - Pediatria Generale e Specialistica
2022
19-feb-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/935717
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