The present study assessed the comparative in vitro killing kinetics of telithromycin, azithromycin and clarithromycin. Minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) were determined against Streptococcus pneumoniae, beta-haemolytic streptococci, Haemophilus influenzae and Moraxella catarrhalis strains characterized by different susceptibilities to beta-lactams and macrolides. For each bacterial species, representative strains were chosen for time-kill studies. Telithromycin showed high activity against all the tested strains with MIC ranging from < or = 0.004 to 0.5 mg/L for streptococci, from 0.008 to 8 mg/L for H. influenzae, and from 0.008 to 0.5 mg/L for M. catarrhalis. In time-kill studies, telithromycin showed an overall superior bactericidal activity in respect to macrolides, particularly against resistant strains. In conclusion, telithromycin proved to possess bactericidal activity against a wide range of respiratory pathogens, including strains resistant to common macrolides.
Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens / L. Drago, E. De Vecchi, L. Nicola, D. Legnani, M.R. Gismondo. - In: APMIS. ACTA PATHOLOGICA, MICROBIOLOGICA ET IMMUNOLOGICA SCANDINAVICA. - ISSN 0903-4641. - 113:10(2005 Oct), pp. 655-663.
|Titolo:||Kinetic bactericidal activity of telithromycin, azithromycin and clarithromycin against respiratory pathogens|
DRAGO, LORENZO (Primo)
LEGNANI, DELFINO (Penultimo)
GISMONDO, MARIA RITA (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||ott-2005|
|Appare nelle tipologie:||01 - Articolo su periodico|