Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer / G. Bogani, V.D. Donato, G. Scambia, F. Landoni, F. Ghezzi, L. Muzii, P.B. Panici, F. Raspagliesi, G. Bogani, V.D. Donato, G. Scambia, F. Ghezzi, J. Casarin, F. Landoni, G. Di Martino, T. Grassi, A.M. Perrone, P. De Iaco, F. Multinu, R. Berretta, V.A. Capozzi, E. Zupi, G. Centini, A. Pellegrino, S. Corso, G. Stevenazzi, A.C. Boschi, G. Comerci, P. Greco, G. Scutiero, F. Sopracordevole, G. Giorda, M. Fichera, T. Simoncini, M. Caretto, E. Sartori, F. Ferrari, A. Cianci, G. Sarpietro, M.G. Matarazzo, P. Giampaolino, G. Bifulco, M. Morelli, M.D. Dio, A. Ferrero, N. Biglia, F. Barra, S. Ferrero, S. Cianci, V. Chiantera, A. Ercoli, S. Schettini, T. Orlando, F.G. Cannone, G. Ettore, A. Puppo, E. Olearo, U.L.R. Maggiore, V. Artuso, I. Palaia, G. Perniola, R. Tripodi, T.G. D'Augè, I. Cuccu, M. Fischetti, G. Santangelo, A. Casorelli, A. Giannini, O. D'Oria, G. Vizzielli, S. Restaino, A. Bergamini, L. Bocciolone, F. Plotti, R. Angioli, G. Mantovani, M. Ceccaroni, C. Cassini, M. Dominoni, L. Giambanco, S. Amodeo, L. Leo, R. Thommaset, D. Raimondo, R. Serrachioli, M. Malzoni, F. Falcone, F. Gorlero, M. Di Luca, E. Busato, S. Kilzie, A. Dell'Acqua, G. Scarfone, P. Vercellini, M. Petrillo, G. Capobianco, A. Ciavattini, L. Mereu, P. Scollo, F. Sorbi, M. Fambrini, F. Romano, G. Ricci, G. Trojano, G.R. Damiani, R. Consonni, N. Di Lorenzo, A. Lippolis, R. Tinelli, L. Aguzzoli, V.D. Mandato, S. Palomba, M. Tripodi, D. Calandra, F. Pellegrini, F. Zullo, D. Surico, V. Remorgida, F. Ruscitto, P. Beretta, E. Vizza, L. Muzii, P.B. Panici, F. Raspagliesi. - In: GYNECOLOGIC ONCOLOGY. - ISSN 0090-8258. - 166:3(2022 Sep), pp. 561-566. [10.1016/j.ygyno.2022.07.022]

Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

A. Dell'Acqua;P. Vercellini;
2022

Abstract

Background: To evaluate the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial on patterns of care and surgery-related morbidity in early-stage cervical cancer. Methods: This is a retrospective, a multi-institutional study evaluating 90-day surgery-related outcomes of patients undergoing treatment for early-stage cervical cancer before (period I: 01/01/2016–06/01/2018) and after (period II: 01/01/2019–06/01/2021) the publication of the results of the LACC trial. Results: Charts of 1295 patients were evaluated: 581 (44.9%) and 714 (55.1%) before and after the publication of the LACC trial, respectively. After the publication of the LACC trial, the number of patients treated with minimally invasive radical hysterectomy decreased from 64.9% to 30.4% (p < 0.001). Overall, 90-day complications occurred in 110 (18.9%) and 119 (16.6%) patients in the period I and period II, respectively (p = 0.795). Similarly, the number of severe (grade 3 or worse) complications did not differ between the two periods (38 (6.5%) vs. 37 (5.1%); p = 0.297). Overall and severe 90-day complications were consistent between periods even evaluating stage IA (p = 0.471), IB1 (p = 0.929), and IB2 (p = 0.074), separately. Conclusions: The present investigation highlighted that in referral centers the shift from minimally invasive to open radical hysterectomy does not influence 90-day surgery-related morbidity.
Complications; Laparoscopy; Morbidity; Radical hysterectomy
Settore MED/40 - Ginecologia e Ostetricia
Article (author)
File in questo prodotto:
File Dimensione Formato  
Bogani et al 2022 .pdf

embargo fino al 09/09/2023

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 210.13 kB
Formato Adobe PDF
210.13 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
1-s2.0-S0090825822004942-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 306.61 kB
Formato Adobe PDF
306.61 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/935387
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact