Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP.

Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review = Effetti avversi di dupilumab nel trattamento della rinosinusite cronica con poliposi nasale / L. Nitro, A.M. Bulfamante, C. Rosso, A.M. Saibene, F. Arnone, G. Felisati, C. Pipolo. - In: ACTA OTORHINOLARYNGOLOGICA ITALICA. - ISSN 1827-675X. - 42:3(2022 Jun), pp. 199-204. [10.14639/0392-100X-N1911]

Adverse effects of dupilumab in chronic rhinosinusitis with nasal polyps. Case report and narrative review = Effetti avversi di dupilumab nel trattamento della rinosinusite cronica con poliposi nasale

L. Nitro
Primo
;
A.M. Bulfamante
Secondo
;
C. Rosso;A.M. Saibene;G. Felisati
Penultimo
;
C. Pipolo
Ultimo
2022-06

Abstract

Herein we review the current literature on the adverse effects related to biological therapy with the monoclonal antibody dupilumab in patients with type 2 inflammation prevalent phenotype chronic rhinosinusitis with nasal polyps (CRSwNP). Our review shows that the side effects of dupilumab may be linked to the prevalent type 2 inflammation phenotype (asthma, dermatitis, CRSwNP). We also report the first case of cutaneous rash as a side effect of dupilumab in a patient with CRSwNP.
adverse effect; chronic rhinosinusitis with nasal polyps; cutaneous rash; dupilumab; type 2 inflammation
Settore MED/31 - Otorinolaringoiatria
Article (author)
File in questo prodotto:
File Dimensione Formato  
review dupilumab acta (2022).pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 307.44 kB
Formato Adobe PDF
307.44 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/934986
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact