Chiral electroanalysis could be regarded as the highest recognition degree in electrochemical sensing, implying the ability to discriminate between specular images of a given electroactive molecule, in terms of peak potential difference. A collection of tests is presented here, focusing on the specific interactions between systematic series of selectors and chiral probes, suggesting interesting clues about the corresponding elements involved in the enantiorecognition process. In particular, voltammetric experiments were performed at chiral electrochemical interphases with implementation of inherently chiral (with the stereogenic element responsible for chirality coinciding with the functional group responsible for the material specific properties [1,2]) or chiral selectors, according to two strategies: i) use of electrode surfaces modified with electrodeposited heterocycle-based inherently chiral oligomer films [1]; ii) use of enantiopure chiral media of high intrinsic order [3]. In all cases neat enantiodiscrimination, in terms of huge peak potential differences, specular by inversion of selector configuration, were observed, confirming the general validity and applicability of this strategy. However, the rationalization of the probe-selector interactions suggests interesting clues about the corresponding elements involved in the enantiorecognition process and therefore being able to obtain the best performances. This combination provides a most desirable background for the development of effective protocols for qualitative and quantitative electroanalysis of chiral electroactive probes.

Wide-scope Enantiodiscrimination at Chiral Electrochemical Interphases: Highlighting structure effects on Probe-Selector Interactions / S. Grecchi, S. Arnaboldi, T. Benincori, H. Lang, L. Guazzelli, F. Fontana, S. Rizzo, P.R. Mussini. ((Intervento presentato al convegno International Symposium on Chirality tenutosi a Chicago : July, 17-20 nel 2022.

Wide-scope Enantiodiscrimination at Chiral Electrochemical Interphases: Highlighting structure effects on Probe-Selector Interactions.

S. Grecchi
Primo
;
S. Arnaboldi
Secondo
;
P.R. Mussini
Ultimo
2022

Abstract

Chiral electroanalysis could be regarded as the highest recognition degree in electrochemical sensing, implying the ability to discriminate between specular images of a given electroactive molecule, in terms of peak potential difference. A collection of tests is presented here, focusing on the specific interactions between systematic series of selectors and chiral probes, suggesting interesting clues about the corresponding elements involved in the enantiorecognition process. In particular, voltammetric experiments were performed at chiral electrochemical interphases with implementation of inherently chiral (with the stereogenic element responsible for chirality coinciding with the functional group responsible for the material specific properties [1,2]) or chiral selectors, according to two strategies: i) use of electrode surfaces modified with electrodeposited heterocycle-based inherently chiral oligomer films [1]; ii) use of enantiopure chiral media of high intrinsic order [3]. In all cases neat enantiodiscrimination, in terms of huge peak potential differences, specular by inversion of selector configuration, were observed, confirming the general validity and applicability of this strategy. However, the rationalization of the probe-selector interactions suggests interesting clues about the corresponding elements involved in the enantiorecognition process and therefore being able to obtain the best performances. This combination provides a most desirable background for the development of effective protocols for qualitative and quantitative electroanalysis of chiral electroactive probes.
Settore CHIM/01 - Chimica Analitica
32
Wide-scope Enantiodiscrimination at Chiral Electrochemical Interphases: Highlighting structure effects on Probe-Selector Interactions / S. Grecchi, S. Arnaboldi, T. Benincori, H. Lang, L. Guazzelli, F. Fontana, S. Rizzo, P.R. Mussini. ((Intervento presentato al convegno International Symposium on Chirality tenutosi a Chicago : July, 17-20 nel 2022.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/934811
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