The development of a visible light-mediated Giese-type reaction using arylboronic acids as aryl radical source is described. The synthetic protocol capitalizes on the employment of environmentally benign metal-free catalyst to forge Csp2-Csp3 bonds. Applications of the methodology to the synthesis of aminoesters and the anti-inflammatory drug nabumetone, either in batch or in flow, are also reported.

Use of acridinium-based photocatalyst in the Giese-type coupling of arylboronic acids with electron poor olefins / M. Caldarelli, L. Laze, L. Piazza, G. Caputo, M. De Amici, G. Papeo. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 103:(2022 Aug 03), pp. 153978.1-153978.5. [10.1016/j.tetlet.2022.153978]

Use of acridinium-based photocatalyst in the Giese-type coupling of arylboronic acids with electron poor olefins

M. De Amici
Penultimo
;
2022-08-03

Abstract

The development of a visible light-mediated Giese-type reaction using arylboronic acids as aryl radical source is described. The synthetic protocol capitalizes on the employment of environmentally benign metal-free catalyst to forge Csp2-Csp3 bonds. Applications of the methodology to the synthesis of aminoesters and the anti-inflammatory drug nabumetone, either in batch or in flow, are also reported.
Visible light photocatalysis; Boronic acids; Giese reaction; Metal free; Nabumetone;
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/06 - Chimica Organica
3-lug-2022
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0040403922004166-main.pdf

embargo fino al 03/07/2024

Descrizione: pre-proofs
Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 540.68 kB
Formato Adobe PDF
540.68 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
1-s2.0-S0040403922004166-main.pdf

accesso riservato

Descrizione: main text (published version)
Tipologia: Publisher's version/PDF
Dimensione 491.09 kB
Formato Adobe PDF
491.09 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/933006
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact