Klinefelter syndrome is the most common sex chromosomal aneuploidy in males. It is well known that patients with this syndrome have greater mortality and morbidity compared to the general population due to cardiovascular diseases and endocrine metabolism disorders. This augmented risk is due both to hypogonadism and to the syndrome itself. Therefore, correct hormonal replacement therapy and early primary prevention are crucial to these patients. Even though different studies are available on this topic in adult patients, only a few authors have focused on the paediatric population. Thus, in this narrative review, we report the current knowledge of metabolic and nutritional aspects in children with Klinefelter syndrome.

Metabolic and nutritional aspects in paediatric patients with Klinefelter syndrome : a narrative review / C. Mameli, G. Fiore, A. Sangiorgio, M. Agostinelli, G. Zichichi, G. Zuccotti, E. Verduci. - In: NUTRIENTS. - ISSN 2072-6643. - 14:10(2022 May 18), pp. 2107.1-2107.16. [10.3390/nu14102107]

Metabolic and nutritional aspects in paediatric patients with Klinefelter syndrome : a narrative review

C. Mameli
Primo
;
G. Fiore;A. Sangiorgio;M. Agostinelli;G. Zichichi;E. Verduci
Ultimo
2022-05-18

Abstract

Klinefelter syndrome is the most common sex chromosomal aneuploidy in males. It is well known that patients with this syndrome have greater mortality and morbidity compared to the general population due to cardiovascular diseases and endocrine metabolism disorders. This augmented risk is due both to hypogonadism and to the syndrome itself. Therefore, correct hormonal replacement therapy and early primary prevention are crucial to these patients. Even though different studies are available on this topic in adult patients, only a few authors have focused on the paediatric population. Thus, in this narrative review, we report the current knowledge of metabolic and nutritional aspects in children with Klinefelter syndrome.
Klinefelter syndrome; body composition; bone metabolism; cardiovascular risk; children; diabetes; hormonal replacement therapy; hypogonadism; metabolic syndrome; adult; child; endocrine system; hormone replacement therapy; humans; male; cardiovascular diseases; hypogonadism; Klinefelter syndrome
Settore MED/38 - Pediatria Generale e Specialistica
Article (author)
File in questo prodotto:
File Dimensione Formato  
nutrients klinefelter 2022.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 1.91 MB
Formato Adobe PDF
1.91 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/931944
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact