The combination of elotuzumab, lenalidomide, and dexamethasone (EloRd) enhanced the clinical benefit over Rd with a manageable toxicity profile in the ELOQUENT-2 trial, leading to its approval in relapsed/refractory multiple myeloma (RRMM). The present study is a 3-year follow-up update of a previously published Italian real-life RRMM cohort of patients treated with EloRd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow-up of 36 months (range 6-55), 236 patients experienced disease progression or died. Median progression-free survival (PFS) and overall survival (OS) were 18.4 and 34 months, respectively. The updated multivariate analyses showed a significant reduction of PFS and OS benefit magnitude only in cases with International Staging System stage III. Major adverse events included grade 3/4 neutropenia (18.5%), anemia (15.4%), lymphocytopenia (12.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 33.9% and 18.9%, respectively. No new safety signals with longer follow-up have been observed. Of 319 patients, 245 (76.7%) reached at least a partial remission. A significantly lower response rate was found in patients previously exposed to lenalidomide. In conclusion, our study confirms that EloRd is a safe and effective regimen for RRMM patients, maintaining benefits across multiple unfavorable subgroups.

Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 3-year follow-up of a multicenter, retrospective clinical experience with 319 cases outside of controlled clinical trials / A. Bruzzese, D. Derudas, M. Galli, E.A. Martino, S. Rocco, C. Conticello, C. Califano, N. Giuliani, S. Mangiacavalli, G. Farina, A. Lombardo, M. Brunori, E. Rossi, E. Antonioli, R. Ria, R. Zambello, N. Di Renzo, G. Mele, G. Marcacci, G. Pietrantuono, G. Palumbo, N. Cascavilla, C. Cerchione, A. Belotti, C. Criscuolo, G. Uccello, P. Curci, E. Vigna, F. Mendicino, E. Iaccino, S. Mimmi, C. Botta, D. Vincelli, N. Sgherza, A. Bonalumi, L. Cupelli, R. Stocchi, M. Martino, S. Ballanti, D. Gangemi, A. Gagliardi, B. Gamberi, A. Pompa, G. Tripepi, F. Frigeri, U. Consoli, S. Bringhen, E. Zamagni, F. Patriarca, V. De Stefano, F. Di Raimondo, S. Palmieri, M.T. Petrucci, M. Offidani, P. Musto, M. Boccadoro, M. Cavo, A. Neri, F. Morabito, M. Gentile. - In: HEMATOLOGICAL ONCOLOGY. - ISSN 0278-0232. - (2022). [Epub ahead of print] [10.1002/hon.3031]

Elotuzumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended 3-year follow-up of a multicenter, retrospective clinical experience with 319 cases outside of controlled clinical trials

A. Neri;
2022

Abstract

The combination of elotuzumab, lenalidomide, and dexamethasone (EloRd) enhanced the clinical benefit over Rd with a manageable toxicity profile in the ELOQUENT-2 trial, leading to its approval in relapsed/refractory multiple myeloma (RRMM). The present study is a 3-year follow-up update of a previously published Italian real-life RRMM cohort of patients treated with EloRd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow-up of 36 months (range 6-55), 236 patients experienced disease progression or died. Median progression-free survival (PFS) and overall survival (OS) were 18.4 and 34 months, respectively. The updated multivariate analyses showed a significant reduction of PFS and OS benefit magnitude only in cases with International Staging System stage III. Major adverse events included grade 3/4 neutropenia (18.5%), anemia (15.4%), lymphocytopenia (12.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 33.9% and 18.9%, respectively. No new safety signals with longer follow-up have been observed. Of 319 patients, 245 (76.7%) reached at least a partial remission. A significantly lower response rate was found in patients previously exposed to lenalidomide. In conclusion, our study confirms that EloRd is a safe and effective regimen for RRMM patients, maintaining benefits across multiple unfavorable subgroups.
dexamethasone; elotuzumab; lenalidomide; multiple myeloma; salvage therapy
Settore MED/15 - Malattie del Sangue
24-mag-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/930455
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