Monoclonal gammopathy of undetermined significance (MGUS) and clonal hematopoiesis (CH) are 2 preclinical clonal expansions of hematopoietic cells, whose prevalence rises with age reaching almost 10% in people of 70 years and older. The increased risk of myeloid malignancies in patients with myeloma is well defined, and the study of the association between these CH and MGUS could help explain this phenomenon. Here, we analyzed a fully clinically annotated dataset of 777 older subjects (median age, 91 years-old) previously screened for prevalence of CH. The prevalence of MGUS and CH was 9.6% and 17.3%, respectively. We detected CH in 9.7% of the MGUS patients, and MGUS in 5.5% of the CH patients. We did not find a significant correlation between the presence of MGUS and CH. Furthermore, the 2 conditions showed a differential association with clinical and laboratory covariates, suggesting that MGUS and CH may represent age-associated unrelated clonal drifts of hematopoietic cells. Confirmatory studies are needed to assess the relevance of CH in plasma cell disorders.

MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort / M.C. Da Vià, M. Lionetti, A. Marella, A. Matera, E. Travaglino, E. Signaroldi, A.A. Galbussera, U. Lucca, S. Mandelli, E. Riva, M. Tettamanti, L. Pettine, A. Pompa, L. Baldini, A. Neri, M.G. Della Porta, N. Bolli. - In: BLOOD ADVANCES. - ISSN 2473-9529. - (2022). [Epub ahead of print] [10.1182/bloodadvances.2021006498]

MGUS and clonal hematopoiesis show unrelated clinical and biological trajectories in an older population cohort

M. Lionetti;A. Marella;A. Matera;E. Signaroldi;L. Pettine;L. Baldini;A. Neri;N. Bolli
2022

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and clonal hematopoiesis (CH) are 2 preclinical clonal expansions of hematopoietic cells, whose prevalence rises with age reaching almost 10% in people of 70 years and older. The increased risk of myeloid malignancies in patients with myeloma is well defined, and the study of the association between these CH and MGUS could help explain this phenomenon. Here, we analyzed a fully clinically annotated dataset of 777 older subjects (median age, 91 years-old) previously screened for prevalence of CH. The prevalence of MGUS and CH was 9.6% and 17.3%, respectively. We detected CH in 9.7% of the MGUS patients, and MGUS in 5.5% of the CH patients. We did not find a significant correlation between the presence of MGUS and CH. Furthermore, the 2 conditions showed a differential association with clinical and laboratory covariates, suggesting that MGUS and CH may represent age-associated unrelated clonal drifts of hematopoietic cells. Confirmatory studies are needed to assess the relevance of CH in plasma cell disorders.
Settore MED/15 - Malattie del Sangue
7-apr-2022
Article (author)
File in questo prodotto:
File Dimensione Formato  
Da Vià_Blood Adv_2022_Epub.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 304.76 kB
Formato Adobe PDF
304.76 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/930453
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact