Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being Staphylococcus aureus, affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis. Here we describe this, analyzing the effects of OS in bone remodeling and discussing the need for new, easy-to-measure and widely available OS biomarkers that will provide valid support in the management of the disease.

Osteomyelitis, Oxidative Stress and Related Biomarkers / L. Massaccesi, E. Galliera, A. Pellegrini, G. Banfi, M.M. Corsi Romanelli. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 11:6(2022), pp. 1061.1-1061.15. [10.3390/antiox11061061]

Osteomyelitis, Oxidative Stress and Related Biomarkers

L. Massaccesi
Primo
;
E. Galliera
Secondo
;
G. Banfi;M.M. Corsi Romanelli
Ultimo
2022

Abstract

Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being Staphylococcus aureus, affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis. Here we describe this, analyzing the effects of OS in bone remodeling and discussing the need for new, easy-to-measure and widely available OS biomarkers that will provide valid support in the management of the disease.
osteomyelitis (OM); reactive oxygen species (ROS); oxidative stress (OS); oxidative stress biomarkers
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Settore MED/05 - Patologia Clinica
Article (author)
File in questo prodotto:
File Dimensione Formato  
antioxidants-11-01061.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 717.61 kB
Formato Adobe PDF
717.61 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/929670
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact