Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.
Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies / N. Hribernik, F. Chiodo, R.J. Pieters, A. Bernardi. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 99:(2022 Jun 08), pp. 153843.1-153843.5. [10.1016/j.tetlet.2022.153843]
Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies
N. HribernikPrimo
;A. Bernardi
Ultimo
2022
Abstract
Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.File | Dimensione | Formato | |
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