Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.

Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies / N. Hribernik, F. Chiodo, R.J. Pieters, A. Bernardi. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 99:(2022 Jun 08), pp. 153843.1-153843.5. [10.1016/j.tetlet.2022.153843]

Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies

N. Hribernik
Primo
;
A. Bernardi
Ultimo
2022

Abstract

Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.
L-Rhamnose, anti-carbohydrate antibodies, glycomimetics, immunotherapy;
Settore CHIM/06 - Chimica Organica
   Multidisciplinary European Joint Doctorate in the Design and Development of Glyco Drugs (PhD4GlycoDrug)
   PhD4GlycoDrug
   EUROPEAN COMMISSION
   H2020
   765581
8-giu-2022
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0040403922002623-main.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 645.59 kB
Formato Adobe PDF
645.59 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/928330
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact