Early complications after lung transplantation (LT) such as acute cellular rejection (ACR) and infections favor the onset of chronic lung allograft dysfunction (CLAD), the major cause of graft failure. Little is known about the pathomolecular signaling in the lung microenvironment that precedes and drives graft rejection. Therefore, we studied the messages delivered by BAL-extracellular vesicles (BAL-EVs) in recipient human primary bronchial cells (HBECs; Fig.1A).
Molecular Insights into the Role of BAL-EVs in Lung Transplant Rejection / V. Vaira, A. Palleschi, A.M. Storaci, S. Franzi, V. Musso, R. Bruschi, L. Morlacchi, V. Rossetti, F. Blasi, M. Nosotti, S. Bosari, S. Ferrero. - In: THE JOURNAL OF HEART AND LUNG TRANSPLANTATION. - ISSN 1053-2498. - 41:suppl. 4(2022 Apr), pp. 44-44. (Intervento presentato al 42. convegno ISHLT Annual Meeting and Scientific Sessions tenutosi a Boston nel 2022).
Molecular Insights into the Role of BAL-EVs in Lung Transplant Rejection
V. Vaira;A. Palleschi;A.M. Storaci;V. Musso;F. Blasi;M. Nosotti;S. Bosari;S. Ferrero
2022
Abstract
Early complications after lung transplantation (LT) such as acute cellular rejection (ACR) and infections favor the onset of chronic lung allograft dysfunction (CLAD), the major cause of graft failure. Little is known about the pathomolecular signaling in the lung microenvironment that precedes and drives graft rejection. Therefore, we studied the messages delivered by BAL-extracellular vesicles (BAL-EVs) in recipient human primary bronchial cells (HBECs; Fig.1A).
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