An 18-month-old Arabian foal characterized by a stallionlike appearance was submitted for cytogenetic and molecular genetics examinations due to abnormalities of external genitalia and the presence of ovotestis-like structures in the abdominal cavity. By RB-banding the animal showed the normal female equine karyotype (2n = 64,XX). Molecular analysis revealed the absence of the SRY and ZFY genes and the presence of ZFX , a typical female equine condition. The entire RSPO1 coding region was examined to exclude its involvement. Although a SNP was found in exon 3, it was not responsible for an amino acid substitution.
Molecular and cytogenetic studies in a case of XX SRY -Negative sex reversal in an Arabian horse / F. Ciotola, S. Albarella, M.P. Pasolini, L. Auletta, L. Esposito, L. Iannuzzi, V. Peretti. - In: SEXUAL DEVELOPMENT. - ISSN 1661-5425. - 6:1-3(2012), pp. 104-107. [10.1159/000331480]
Molecular and cytogenetic studies in a case of XX SRY -Negative sex reversal in an Arabian horse
L. Auletta;
2012
Abstract
An 18-month-old Arabian foal characterized by a stallionlike appearance was submitted for cytogenetic and molecular genetics examinations due to abnormalities of external genitalia and the presence of ovotestis-like structures in the abdominal cavity. By RB-banding the animal showed the normal female equine karyotype (2n = 64,XX). Molecular analysis revealed the absence of the SRY and ZFY genes and the presence of ZFX , a typical female equine condition. The entire RSPO1 coding region was examined to exclude its involvement. Although a SNP was found in exon 3, it was not responsible for an amino acid substitution.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
