Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
Covid-19 infection in children, infants and pregnant subjects: An overview of recent insights and therapies / G. Malcangi, A.D. Inchingolo, A.M. Inchingolo, L. Santacroce, G. Marinelli, A. Mancini, L. Vimercati, M.E. Maggiore, M.T. D'Oria, D. Hazballa, I.R. Bordea, E. Xhajanka, A. Scarano, M. Farronato, G.M. Tartaglia, D. Giovanniello, L. Nucci, R. Serpico, G. Sammartino, L. Capozzi, A. Parisi, M. Di Domenico, F. Lorusso, M. Contaldo, F. Inchingolo, G. Dipalma. - In: MICROORGANISMS. - ISSN 2076-2607. - 9:9(2021 Sep), pp. 1964.1-1964.31. [10.3390/microorganisms9091964]
Covid-19 infection in children, infants and pregnant subjects: An overview of recent insights and therapies
A.M. Inchingolo;M. Farronato;G.M. Tartaglia;
2021
Abstract
Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
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