Di Mitri et al. show that CXCR2 blockade in prostate cancer triggers TAMs re-education, leading to tumor inhibition. CXCR2-KO monocytes infused in Ptenpc−/−; Trp53pc−/− tumor-bearing mice differentiate into TNFα-releasing pro-inflammatory macrophages that induce senescence in tumor cells. PTEN-null tumors display higher sensitivity to TNF-α-induced senescence because of TNFR1 upregulation.
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer / D. Di Mitri, M. Mirenda, J. Vasilevska, A. Calcinotto, N. Delaleu, A. Revandkar, V. Gil, G. Boysen, M. Losa, S. Mosole, E. Pasquini, R. D'Antuono, M. Masetti, E. Zagato, G. Chiorino, P. Ostano, A. Rinaldi, L. Gnetti, M. Graupera, A.R. Martins Figueiredo Fonseca, R. Pereira Mestre, D. Waugh, S. Barry, J. De Bono, A. Alimonti. - In: CELL REPORTS. - ISSN 2211-1247. - 28:8(2019 Aug 20), pp. 2156-2168.e5. [10.1016/j.celrep.2019.07.068]
Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer
E. Zagato;
2019
Abstract
Di Mitri et al. show that CXCR2 blockade in prostate cancer triggers TAMs re-education, leading to tumor inhibition. CXCR2-KO monocytes infused in Ptenpc−/−; Trp53pc−/− tumor-bearing mice differentiate into TNFα-releasing pro-inflammatory macrophages that induce senescence in tumor cells. PTEN-null tumors display higher sensitivity to TNF-α-induced senescence because of TNFR1 upregulation.
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