Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.
The long-term effect of AHSCT on MRI measures of MS evolution: A five-year follow-up study / L. Roccatogliata, M.A. Rocca, P. Valsasina, L. Bonzano, M.P. Sormani, R. Saccardi, G.L. Mancardi, M. Filippi, M.G. Marrosu, G. La Nasa, E. Cocco, V. Cherchi, A. Lugaresi, P. Di Bartolomeo, D. Farina, C. Ialori, A. Tartaro, L. Massacesi, F. Pagliai, A. Bosi, A. Repice, A. Konze, F. Sardanelli, E. Capello, A. Murialdo, F. Gualandi, R.C. Parodi, L. Dogliotti, A. Marmont, M. Inglese, G. Comi, A. Donelli, E. Merelli, F. Casoni, F. Cavalleri, A. Bertolotto, A. Guerrasio, M. Capobianco, S. Duca, G. Meucci, F. Papineschi, S. Mosti, A. Abruzzese. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 13:8(2007), pp. 1068-1070. [10.1177/1352458507076982]
The long-term effect of AHSCT on MRI measures of MS evolution: A five-year follow-up study
F. Sardanelli;
2007
Abstract
Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.
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