The supramolecular assembly of acetylsalicylic acid to a merocyanine-Zn complex translates into a photo-controllable drug delivery system. Herein, we present the synthesis and spectroscopic analysis of a three-component assembly combining a spiropyran derivative, a zinc(ii) cation, and acetylsalicylic acid. The ON/OFF system can be modulated by safe and easily affordable stimuli, for the specific delivery of more than one active compound. Our results confirm the formation of a ternary system in solution, where the behaviour is dominated by photo-induced responses, and pave the way for the use of such smart platforms for medicinal chemistry purposes.
Spiropyrans for light-controlled drug delivery / F. Cardano, E. Del Canto, S. Giordani. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 48:41(2019 Jul), pp. 15537-15544. [10.1039/c9dt02092f]
Spiropyrans for light-controlled drug delivery
F. CardanoPrimo
;
2019
Abstract
The supramolecular assembly of acetylsalicylic acid to a merocyanine-Zn complex translates into a photo-controllable drug delivery system. Herein, we present the synthesis and spectroscopic analysis of a three-component assembly combining a spiropyran derivative, a zinc(ii) cation, and acetylsalicylic acid. The ON/OFF system can be modulated by safe and easily affordable stimuli, for the specific delivery of more than one active compound. Our results confirm the formation of a ternary system in solution, where the behaviour is dominated by photo-induced responses, and pave the way for the use of such smart platforms for medicinal chemistry purposes.
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