A short period (1-2 hours) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver transplantation. Machine perfusion time is occasionally prolonged for logistical reasons, but it is unknown if prolonged HOPE is safe and compromises outcomes. We conducted a multicenter, observational cohort study of patients transplanted with a liver preserved by prolonged (≥4 hours) HOPE. Postoperative biochemistry, complications, and survival were evaluated. The cohort included 93 recipients from 12 European transplant centers between 2014-2021. The most common reason to prolong HOPE was the lack of an available operating room to start the transplant procedure. Grafts underwent HOPE for a median (range) of 4:42h (4:00-8:35h) with a total preservation time of 10:50h (5:50h-20:50h). Postoperative peak ALT was 675 IU/L (interquartile range 419-1378 IU/L). The incidence of postoperative complications was low, and 1-year graft and patient survival were 94%, and 88%, respectively. To conclude, good outcomes are achieved after transplantation of donor livers preserved with prolonged (median 4:42 hours) HOPE, leading to a total preservation time of almost 21 hours. These results suggest that simple, end-ischemic HOPE may be utilized for safe extension of the preservation time to ease transplantation logistics.
Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: a European observational cohort study / I.M.A. Brüggenwirth, M. Mueller, V.A. Lantinga, S. Camagni, R. De Carlis, L. De Carlis, M. Colledan, D. Dondossola, M. Drefs, J. Eden, D. Ghinolfi, D. Koliogiannis, G. Lurje, T.M. Manzia, D. Monbaliu, P. Muiesan, D. Patrono, J. Pratschke, R. Romagnoli, M. Rayar, F. Roma, A. Schlegel, P. Dutkowski, R.J. Porte, V.E. de Meijer. - In: AMERICAN JOURNAL OF TRANSPLANTATION. - ISSN 1600-6135. - 22:7(2022 Jul), pp. 1842-1851. [10.1111/ajt.17037]
Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: a European observational cohort study
D. Dondossola;P. Muiesan;
2022
Abstract
A short period (1-2 hours) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver transplantation. Machine perfusion time is occasionally prolonged for logistical reasons, but it is unknown if prolonged HOPE is safe and compromises outcomes. We conducted a multicenter, observational cohort study of patients transplanted with a liver preserved by prolonged (≥4 hours) HOPE. Postoperative biochemistry, complications, and survival were evaluated. The cohort included 93 recipients from 12 European transplant centers between 2014-2021. The most common reason to prolong HOPE was the lack of an available operating room to start the transplant procedure. Grafts underwent HOPE for a median (range) of 4:42h (4:00-8:35h) with a total preservation time of 10:50h (5:50h-20:50h). Postoperative peak ALT was 675 IU/L (interquartile range 419-1378 IU/L). The incidence of postoperative complications was low, and 1-year graft and patient survival were 94%, and 88%, respectively. To conclude, good outcomes are achieved after transplantation of donor livers preserved with prolonged (median 4:42 hours) HOPE, leading to a total preservation time of almost 21 hours. These results suggest that simple, end-ischemic HOPE may be utilized for safe extension of the preservation time to ease transplantation logistics.File | Dimensione | Formato | |
---|---|---|---|
Prolonged preservation by hypothermic machine perfusion.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
975.8 kB
Formato
Adobe PDF
|
975.8 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.