In the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory synaptic transmission and the induction of different forms of synaptic plasticity. The modulation of the AMPAR tetramer subunit composition at synapses defines the functional properties of the receptor. During the last twenty years, several studies have evaluated the roles played by each subunit, from GluA1 to GluA4, in both physiological and pathological conditions. Here, we have focused our attention on GluA3-containing AMPARs, addressing their functional role in synaptic transmission and synaptic plasticity and their involvement in a variety of brain disorders. Although several aspects remain to be fully understood, GluA3 is a widely expressed and functionally relevant subunit in AMPARs involved in several brain circuits, and its pharmacological modulation could represent a novel approach for the rescue of altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders.

GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders / M. Italia, E. Ferrari, M. Di Luca, F. Gardoni. - In: NEUROBIOLOGY OF DISEASE. - ISSN 0969-9961. - 161:(2021 Oct 29), pp. 105539.1-105539.10. [10.1016/j.nbd.2021.105539]

GluA3-containing AMPA receptors: From physiology to synaptic dysfunction in brain disorders

M. Italia
Primo
;
E. Ferrari
Secondo
;
M. Di Luca
Penultimo
;
F. Gardoni
Ultimo
2021

Abstract

In the mammalian brain, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) play a fundamental role in the activation of excitatory synaptic transmission and the induction of different forms of synaptic plasticity. The modulation of the AMPAR tetramer subunit composition at synapses defines the functional properties of the receptor. During the last twenty years, several studies have evaluated the roles played by each subunit, from GluA1 to GluA4, in both physiological and pathological conditions. Here, we have focused our attention on GluA3-containing AMPARs, addressing their functional role in synaptic transmission and synaptic plasticity and their involvement in a variety of brain disorders. Although several aspects remain to be fully understood, GluA3 is a widely expressed and functionally relevant subunit in AMPARs involved in several brain circuits, and its pharmacological modulation could represent a novel approach for the rescue of altered glutamatergic synapses associated with neurodegenerative and neurodevelopmental disorders.
AMPA receptors; Autoimmunity; Dendritic spines; Glutamate; Neurodegeneration; Synaptic plasticity; Synaptic transmission
Settore BIO/14 - Farmacologia
   Identifying Disease signatures of degenerative dementias: a focus on autoimmunity and inflammation
   MINISTERO DELLA SALUTE
   RF-2019-12369272
29-ott-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/918474
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