Background and purpose Cognitive dysfunction has been observed following recovery from COVID-19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and eventual associations with specific clinical variables. Methods Seventy-six patients (aged 22-74 years) who had been hospitalized for COVID-19 were recruited. Patients received neuropsychological assessments at 5 (n = 76) and 12 months (n = 53) from hospital discharge. Results Over half (63.2%) of the patients had deficits in at least one test at 5 months. Compared to the assessment at 5 months, verbal memory, attention and processing speed improved significantly after 1 year (all p < 0.05), whereas visuospatial memory did not (all p > 0.500). The most affected domains after 1 year were processing speed (28.3%) and long-term visuospatial (18.1%) and verbal (15.1%) memory. Lower PaO2/FiO(2) ratios in the acute phase were associated with worse verbal long-term memory (p = 0.029) and visuospatial learning (p = 0.041) at 5 months. Worse visuospatial long-term memory at 5 months was associated with hyposmia (p = 0.020) and dysgeusia (p = 0.037). Conclusion Our study expands the results from previous studies showing that cognitive impairment can still be observed after 1 year. Patients with severe COVID-19 should receive periodic cognitive follow-up evaluations, as cognitive deficits in recovered patients could have social and occupational implications.

One‐Year Cognitive Follow‐Up of COVID‐19 Hospitalized Patients / R. Ferrucci, M. Dini, C. Rosci, A. Capozza, E. Groppo, M.R. Reitano, E. Allocco, B. Poletti, A. Brugnera, F. Bai, A. Monti, N. Ticozzi, V. Silani, S. Centanni, A. D’Arminio Monforte, L. Tagliabue, A. Priori. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - 29:7(2022 Jul), pp. 2006-2014. [10.1111/ene.15324]

One‐Year Cognitive Follow‐Up of COVID‐19 Hospitalized Patients

R. Ferrucci
Primo
;
M. Dini
Secondo
;
B. Poletti;F. Bai;N. Ticozzi;V. Silani;S. Centanni;A. D’Arminio Monforte;A. Priori
2022

Abstract

Background and purpose Cognitive dysfunction has been observed following recovery from COVID-19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and eventual associations with specific clinical variables. Methods Seventy-six patients (aged 22-74 years) who had been hospitalized for COVID-19 were recruited. Patients received neuropsychological assessments at 5 (n = 76) and 12 months (n = 53) from hospital discharge. Results Over half (63.2%) of the patients had deficits in at least one test at 5 months. Compared to the assessment at 5 months, verbal memory, attention and processing speed improved significantly after 1 year (all p < 0.05), whereas visuospatial memory did not (all p > 0.500). The most affected domains after 1 year were processing speed (28.3%) and long-term visuospatial (18.1%) and verbal (15.1%) memory. Lower PaO2/FiO(2) ratios in the acute phase were associated with worse verbal long-term memory (p = 0.029) and visuospatial learning (p = 0.041) at 5 months. Worse visuospatial long-term memory at 5 months was associated with hyposmia (p = 0.020) and dysgeusia (p = 0.037). Conclusion Our study expands the results from previous studies showing that cognitive impairment can still be observed after 1 year. Patients with severe COVID-19 should receive periodic cognitive follow-up evaluations, as cognitive deficits in recovered patients could have social and occupational implications.
cognition; COVID-19; long-COVID; neuropsychological evaluation;
Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica
Settore MED/26 - Neurologia
Settore MED/17 - Malattie Infettive
Settore MED/10 - Malattie dell'Apparato Respiratorio
lug-2022
14-mar-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/916214
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