Purpose: To investigate choroidal granulomas visualized by indocyanine green angiography (ICGA) and Optical Coherence Tomography Angiography (OCTA) in response to treatment. Methods: Ten eyes of eight patients with tubercular, sarcoid or Vogt-Koyanagi-Harada associated choroidal granulomas were evaluated in this multicentric study. All patients underwent ICGA and OCTA at baseline, 1 and 3 months after treatment onset. Granulomas were identified as hypofluorescent lesions on intermediate ICGA phases. Late ICGA behavior and OCTA visualization were assessed. Results: On baseline intermediate ICGA, 222 choroidal granulomas were detected. Overall, 174/222 granulomas were detected on baseline OCTA images. At 1 month, 28% of lesions were healed and 48 late ICGA hyper-fluorescent lesions were identified. At 3 months, 63% of baseline lesions were healed, with 33 persistent late hyper-fluorescent lesions. OCTA sensitivity was reduced at 1 and 3 months compared to baseline. Some flow-voids detected on OCTA at 1 and 3 months did not correspond to any visible lesion on ICGA. Conclusions: Different healing behaviors of choroidal granulomas were identified combining ICGA and OCTA analysis. Late ICGA hyper-fluorescent lesions may be the consequence of a possible fibrotic shift. Structural changes in the choroid may persist after active granulomas resolution resulting in persistent flow voids on OCTA.

Longitudinal follow-up of Choroidal Granulomas with Indocyanine Green Angiography And Optical Coherence Tomography Angiography: a lesion-based analysis / S. Parrulli, A. Invernizzi, D. Monteduro, F. Zicarelli, M. Oldani, G. Staurenghi, E. Woodstock, S. Hay, P. Neri, F. Pichi. - In: RETINA. - ISSN 0275-004X. - 42:5(2022 May), pp. 906-914. [10.1097/IAE.0000000000003405]

Longitudinal follow-up of Choroidal Granulomas with Indocyanine Green Angiography And Optical Coherence Tomography Angiography: a lesion-based analysis

S. Parrulli
Primo
;
A. Invernizzi
Secondo
;
D. Monteduro;F. Zicarelli;M. Oldani;G. Staurenghi;F. Pichi
2022

Abstract

Purpose: To investigate choroidal granulomas visualized by indocyanine green angiography (ICGA) and Optical Coherence Tomography Angiography (OCTA) in response to treatment. Methods: Ten eyes of eight patients with tubercular, sarcoid or Vogt-Koyanagi-Harada associated choroidal granulomas were evaluated in this multicentric study. All patients underwent ICGA and OCTA at baseline, 1 and 3 months after treatment onset. Granulomas were identified as hypofluorescent lesions on intermediate ICGA phases. Late ICGA behavior and OCTA visualization were assessed. Results: On baseline intermediate ICGA, 222 choroidal granulomas were detected. Overall, 174/222 granulomas were detected on baseline OCTA images. At 1 month, 28% of lesions were healed and 48 late ICGA hyper-fluorescent lesions were identified. At 3 months, 63% of baseline lesions were healed, with 33 persistent late hyper-fluorescent lesions. OCTA sensitivity was reduced at 1 and 3 months compared to baseline. Some flow-voids detected on OCTA at 1 and 3 months did not correspond to any visible lesion on ICGA. Conclusions: Different healing behaviors of choroidal granulomas were identified combining ICGA and OCTA analysis. Late ICGA hyper-fluorescent lesions may be the consequence of a possible fibrotic shift. Structural changes in the choroid may persist after active granulomas resolution resulting in persistent flow voids on OCTA.
Settore MED/30 - Malattie Apparato Visivo
mag-2022
12-gen-2022
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/914323
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