Background: The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the "Stomach cancer Pooling (StoP) Project", including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56-0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55-0.86) for onions and 0.83 (95% CI, 0.75-0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29-0.86) but not European (OR 0.96, 95% CI, 0.81-1.13) and American (OR 0.66, 95% CI, 0.39-1.11) studies. Results were consistent across all other strata. Conclusions: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.

Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project / M. Dalmartello, F. Turati, Z. Zhang, N. Lunet, M. Rota, R. Bonzi, C. Galeone, G. Martimianaki, D. Palli, M. Ferraroni, G. -P- Yu, S. Morais, R. Malekzadeh, L. López-Carrillo, D. Zaridze, D. Maximovitch, N. Aragonés, G. Fernández-Tardón, V. Martin, J. Vioque, M. Garcia de la Hera, M.P. Curado, F.J.F. Coimbra, P. Assumpcao, M. Pakseresht, J. Hu, R.U. Hernández-Ramírez, M.H. Ward, F. Pourfarzi, L. Mu, S. Tsugane, A. Hidaka, P. Lagiou, A. Lagiou, A. Trichopoulou, A. Karakatsani, P. Boffetta, M.C. Camargo, E. Negri, C. La Vecchia, C. Pelucchi. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - (2022), pp. 1-10. [Epub ahead of print] [10.1038/s41416-022-01750-5]

Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project

M. Dalmartello
Primo
;
F. Turati
Secondo
;
R. Bonzi;G. Martimianaki;M. Ferraroni;E. Negri;C. La Vecchia
Penultimo
;
C. Pelucchi
Ultimo
2022

Abstract

Background: The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods: We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the "Stomach cancer Pooling (StoP) Project", including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results: Total allium vegetables intake was inversely associated with GC risk. The pooled OR for the highest versus the lowest study-specific tertile of consumption was 0.71 (95% confidence interval, CI, 0.56-0.90), with substantial heterogeneity across studies (I2 > 50%). Pooled ORs for high versus low consumption were 0.69 (95% CI, 0.55-0.86) for onions and 0.83 (95% CI, 0.75-0.93) for garlic. The inverse association with allium vegetables was evident in Asian (OR 0.50, 95% CI, 0.29-0.86) but not European (OR 0.96, 95% CI, 0.81-1.13) and American (OR 0.66, 95% CI, 0.39-1.11) studies. Results were consistent across all other strata. Conclusions: In a worldwide consortium of epidemiological studies, we found an inverse association between allium vegetables and GC, with a stronger association seen in Asian studies. The heterogeneity of results across geographic regions and possible residual confounding suggest caution in results interpretation.
SToP consortium; gastric cacner; allium vegetables; allium
Settore MED/01 - Statistica Medica
24-feb-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/912625
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