Cytokinins are naturally occurring adenine derivatives whose physiological role is that of growth regulators in plants and that show also many other activities either in plants and in mammalian cells. In plants, they can be found mainly as free bases ((N6-substituted adenines, CKs), but also as the corresponding N9- ribosides (N6-substituted adenosines, CKRs). In mammalian cells, CKRs are, in general, more active than CKs. In order to evaluate the intrinsic in vitro antioxidant capacity of some significant CKRs, their scavenging activity against synthetic radicals that are at the basis of well-established antioxidant assays (ORAC, TEAC, DPPH) has been evaluated. The results of the in vitro scavenging activity of biologically relevant radicals such as hydroxyl (HO•), superoxide (O2.-) and lipid peroxides (R-OO.) are reported and discussed.

Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N⁶-substituted adenosines) by in vitro chemical assays [Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N6-substituted adenosines) by in vitro chemical assays] / A. Brizzolari, M.C. Foti, L. Saso, P. Ciuffreda, J. Lazarevic, E. Santaniello. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2022), pp. 1-5. [Epub ahead of print] [10.1080/14786419.2022.2037590]

Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N⁶-substituted adenosines) by in vitro chemical assays [Evaluation of the radical scavenging activity of some representative isoprenoid and aromatic cytokinin ribosides (N6-substituted adenosines) by in vitro chemical assays]

A. Brizzolari;P. Ciuffreda;
2022

Abstract

Cytokinins are naturally occurring adenine derivatives whose physiological role is that of growth regulators in plants and that show also many other activities either in plants and in mammalian cells. In plants, they can be found mainly as free bases ((N6-substituted adenines, CKs), but also as the corresponding N9- ribosides (N6-substituted adenosines, CKRs). In mammalian cells, CKRs are, in general, more active than CKs. In order to evaluate the intrinsic in vitro antioxidant capacity of some significant CKRs, their scavenging activity against synthetic radicals that are at the basis of well-established antioxidant assays (ORAC, TEAC, DPPH) has been evaluated. The results of the in vitro scavenging activity of biologically relevant radicals such as hydroxyl (HO•), superoxide (O2.-) and lipid peroxides (R-OO.) are reported and discussed.
chemical assays; cytokinins (bases and ribosides); in vitro antioxidant activity; Oxidative stress; radicals;
Settore BIO/10 - Biochimica
2022
7-feb-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/911244
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