3D scaffolds for tissue engineering typically need to adopt a dynamic culture to foster cell distribution and survival throughout the scaffold. It is, therefore, crucial to know fluids' behavior inside the scaffold architecture, especially for complex porous ones. Here we report a comparison between simulated and measured permeability of a porous 3D scaffold, focusing on different modeling parameters. The scaffold features were extracted by microcomputed tomography (µCT) and representative volume elements were used for the computational fluid-dynamic analyses. The objective was to investigate the sensitivity of the model to the degree of detail of the µCT image and the elements of the mesh. These findings highlight the pros and cons of the modeling strategy adopted and the importance of such parameters in analyzing fluid behavior in 3D scaffolds.

Effects of the 3D Geometry Reconstruction on the Estimation of 3D Porous Scaffold Permeability / D. Guarnera, F. Iberite, M. Piazzoni, I. Gerges, T. Santaniello, L. Vannozzi, C. Lenardi, L. Ricotti (ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY). - In: EMBC[s.l] : Institute of Electrical and Electronics Engineers (IEEE), 2021. - ISBN 978-1-7281-1179-7. - pp. 4403-4407 (( Intervento presentato al 45. convegno Annual International Conference of the IEEE Engineering in Medicine & Biology Society : 1 - 5 November tenutosi a Mexico nel 2021 [10.1109/EMBC46164.2021.9629664].

Effects of the 3D Geometry Reconstruction on the Estimation of 3D Porous Scaffold Permeability

M. Piazzoni;I. Gerges;T. Santaniello;C. Lenardi
Penultimo
;
L. Ricotti
Ultimo
2021

Abstract

3D scaffolds for tissue engineering typically need to adopt a dynamic culture to foster cell distribution and survival throughout the scaffold. It is, therefore, crucial to know fluids' behavior inside the scaffold architecture, especially for complex porous ones. Here we report a comparison between simulated and measured permeability of a porous 3D scaffold, focusing on different modeling parameters. The scaffold features were extracted by microcomputed tomography (µCT) and representative volume elements were used for the computational fluid-dynamic analyses. The objective was to investigate the sensitivity of the model to the degree of detail of the µCT image and the elements of the mesh. These findings highlight the pros and cons of the modeling strategy adopted and the importance of such parameters in analyzing fluid behavior in 3D scaffolds.
Permeability; Porosity; X-Ray Microtomography; Tissue Engineering; Tissue Scaffolds;
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Institute of Electrical and Electronics Engineers (IEEE)
Book Part (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/908583
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