In the last decades, cannabinoid receptor 2 (CB2R) has continued to receive attention as a key therapeutic target in neuroprotection. Indeed, several findings highlight the neuroprotective effects of CB2R through suppression of both neuronal excitability and reactive microglia. Additionally, CB2R seems to be a more promising target than cannabinoid receptor 1 (CB1R) thanks to the lack of central side effects, its lower expression levels in the central nervous system (CNS), and its inducibility, since its expression enhances quickly in the brain following pathological conditions. This review aims to provide a thorough overview of the main natural and synthetic selective CB2R modulators, their chemical classification and their potential therapeutic usefulness in neuroprotection, a crucial aspect for the treatment of neurodegenerative diseases.

Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases / R. Ferrisi, C. Ceni, S. Bertini, M. Macchia, C. Manera, F. Gado. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 170(2021 Aug), pp. 105607.1-105607.23. [10.1016/j.phrs.2021.105607]

Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases

R. Ferrisi;F. Gado
2021

Abstract

In the last decades, cannabinoid receptor 2 (CB2R) has continued to receive attention as a key therapeutic target in neuroprotection. Indeed, several findings highlight the neuroprotective effects of CB2R through suppression of both neuronal excitability and reactive microglia. Additionally, CB2R seems to be a more promising target than cannabinoid receptor 1 (CB1R) thanks to the lack of central side effects, its lower expression levels in the central nervous system (CNS), and its inducibility, since its expression enhances quickly in the brain following pathological conditions. This review aims to provide a thorough overview of the main natural and synthetic selective CB2R modulators, their chemical classification and their potential therapeutic usefulness in neuroprotection, a crucial aspect for the treatment of neurodegenerative diseases.
CB2 cannabinoid receptor; CB2 receptor allosteric modulators; CB2 receptor ligands; Endocannabinoid system; Neurodegenerative disorders; Neuroprotection; Phytocannabinoids; Animals; Brain; Endocannabinoids; Humans; Ligands; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Receptor, Cannabinoid, CB2; Signal Transduction; Nerve Degeneration
Settore BIO/14 - Farmacologia
ago-2021
3-giu-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/908005
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