OBJECTIVE: This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. METHODS: A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. RESULTS: Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. CONCLUSIONS: These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.

Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium / G. Martimianaki, P. Bertuccio, G. Alicandro, C. Pelucchi, F. Bravi, G. Carioli, R. Bonzi, C.S. Rabkin, L.M. Liao, R. Sinha, K. Johnson, J. Hu, D. Palli, M. Ferraroni, N. Lunet, S. Morais, S. Tsugane, A. Hidaka, G.S. Hamada, L. Lopez-Carrillo, R.U. Hernandez-Ramirez, D. Zaridze, D. Maximovitch, N. Aragones, V. Martin, M.H. Ward, J. Vioque, M. Garcia de la Hera, Z.-. Zhang, R.C. Kurtz, P. Lagiou, A. Lagiou, A. Trichopoulou, A. Karakatsani, R. Malekzadeh, M.C. Camargo, M.P. Curado, S. Boccia, B. Boffetta, E. Negri, C. La Vecchia. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - 31:2(2022 Mar 01), pp. 117-127. [10.1097/CEJ.0000000000000680]

Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

G. Martimianaki;P. Bertuccio
;
G. Alicandro;C. Pelucchi;F. Bravi;G. Carioli;R. Bonzi;M. Ferraroni;E. Negri
Penultimo
;
C. La Vecchia
Ultimo
2022-03-01

Abstract

OBJECTIVE: This study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls. METHODS: A two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer. RESULTS: Compared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only. CONCLUSIONS: These findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.
cardia cancer; case-control study; coffee; gastric cancer; pooled analysis
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/905915
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