FHIT is a tumor suppressor gene that is frequently inactivated in human cancer. Although the Fhit protein is known to hydrolyze diadenosine triphosphate (Ap3A), this hydrolase activity is not required for Fhit-mediated oncosuppression. Indeed, the molecular mechanisms and the regulatory elements of Fhit oncosuppression are largely unknown. Here, we review physiological and pathological aspects of Fhit in the context of the ApnA family of signalling molecules, as well as the involvement of Fhit in apoptosis and the cell cycle in cancer models. We also discuss recent findings of novel Fhit interactions that may lead to new hypothesis about biochemical mechanisms underlying the oncosuppressor activity of this gene.

Diadenosines as FHIT-ness instructors / M. Campiglio, F. Bianchi, F. Andriani, G. Sozzi, E. Tagliabue, S. Menard, L. Roz. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - 208:2(2006 Aug), pp. 274-281. [10.1002/jcp.20633]

Diadenosines as FHIT-ness instructors

F. Bianchi
Secondo
;
2006

Abstract

FHIT is a tumor suppressor gene that is frequently inactivated in human cancer. Although the Fhit protein is known to hydrolyze diadenosine triphosphate (Ap3A), this hydrolase activity is not required for Fhit-mediated oncosuppression. Indeed, the molecular mechanisms and the regulatory elements of Fhit oncosuppression are largely unknown. Here, we review physiological and pathological aspects of Fhit in the context of the ApnA family of signalling molecules, as well as the involvement of Fhit in apoptosis and the cell cycle in cancer models. We also discuss recent findings of novel Fhit interactions that may lead to new hypothesis about biochemical mechanisms underlying the oncosuppressor activity of this gene.
animals; dinucleoside phosphates; humans; models, biological; neoplasm proteins; genes, tumor suppressor
Settore BIO/17 - Istologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/905827
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