As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested in vitro, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.

Functionalized Scintillating Nanotubes for Simultaneous Radio- And Photodynamic Therapy of Cancer / I. Villa, C. Villa, R. Crapanzano, V. Secchi, M. Tawfilas, E. Trombetta, L. Porretti, A. Brambilla, M. Campione, Y. Torrente, A. Vedda, A. Monguzzi. - In: ACS APPLIED MATERIALS & INTERFACES. - ISSN 1944-8244. - 13:11(2021 Mar 24), pp. 12997-13008. [10.1021/acsami.1c02504]

Functionalized Scintillating Nanotubes for Simultaneous Radio- And Photodynamic Therapy of Cancer

C. Villa;E. Trombetta;Y. Torrente;
2021

Abstract

As a model radio-photodynamic therapy (RPDT) agent, we developed a multicomponent nanomaterial by anchoring conjugated chromophores on the surface of scintillating chrysotile nanotubes. Its ultimate composition makes the system a scintillation-activated photosensitizer for the singlet oxygen production. This nanomaterial shows a remarkable ability to enhance the production of singlet oxygen in an aqueous environment, under X-ray irradiation, boosting its production by almost 1 order of magnitude. Its efficiency as a coadjutant for radiotherapy has been tested in vitro, showing a striking efficacy in enhancing both the prompt cytotoxicity of the ionizing radiation and the long-term cytotoxicity given by radiation-activated apoptosis. Notably, the beneficial activity of the RPDT agent is prominent at low levels of delivered doses comparable to the one employed in clinical treatments. This opens the possibility of effectively reducing the therapy exposure and consequently undesired collateral effects due to prolonged exposure of patients to high-energy radiation.
nanomaterials; photodynamic therapy; radiotherapy; scintillating nanoparticles; singlet oxygen; Asbestos, Serpentine; Cell Line, Tumor; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; X-Rays; Nanotubes
Settore MED/26 - Neurologia
24-mar-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/905530
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