Nutraceutical products possess various anti-inflammatory, antiarrhythmic, cardiotonic, and antioxidant pharmacological activities that could be useful in preventing oxidative damage, mainly induced by reactive oxygen species. Previously published data showed that a mixture of polyphenols and polyunsaturated fatty acids, mediate an antioxidative response in mdx mice, Duchenne muscular dystrophy animal model. Dystrophic muscles are characterized by low regenerative capacity, fibrosis, fiber necrosis, inflammatory process, altered autophagic flux and inadequate anti-oxidant response. FLAVOmega β is a mixture of flavonoids and docosahexaenoic acid. In this study, we evaluated the role of these supplements in the amelioration of the pathological phenotype in dystrophic mice through in vitro and in vivo assays. FLAVOmega β reduced inflammation and fibrosis, dampened reactive oxygen species production, and induced an oxidative metabolic switch of myofibers, with consequent increase of mitochondrial activity, vascularization, and fatigue resistance. Therefore, we propose FLAVOmega β as food supplement suitable for preventing muscle weakness, delaying inflammatory milieu, and sustaining physical health in patients affected from DMD.

Flavonoids and omega3 prevent muscle and cardiac damage in duchenne muscular dystrophy animal model / L. Tripodi, D. Molinaro, A. Farini, G. Cadiao, C. Villa, Y. Torrente. - In: CELLS. - ISSN 2073-4409. - 10:11(2021 Nov), pp. 2917.1-2917.19. [10.3390/cells10112917]

Flavonoids and omega3 prevent muscle and cardiac damage in duchenne muscular dystrophy animal model

L. Tripodi
Primo
;
C. Villa
Penultimo
;
Y. Torrente
Ultimo
2021-11

Abstract

Nutraceutical products possess various anti-inflammatory, antiarrhythmic, cardiotonic, and antioxidant pharmacological activities that could be useful in preventing oxidative damage, mainly induced by reactive oxygen species. Previously published data showed that a mixture of polyphenols and polyunsaturated fatty acids, mediate an antioxidative response in mdx mice, Duchenne muscular dystrophy animal model. Dystrophic muscles are characterized by low regenerative capacity, fibrosis, fiber necrosis, inflammatory process, altered autophagic flux and inadequate anti-oxidant response. FLAVOmega β is a mixture of flavonoids and docosahexaenoic acid. In this study, we evaluated the role of these supplements in the amelioration of the pathological phenotype in dystrophic mice through in vitro and in vivo assays. FLAVOmega β reduced inflammation and fibrosis, dampened reactive oxygen species production, and induced an oxidative metabolic switch of myofibers, with consequent increase of mitochondrial activity, vascularization, and fatigue resistance. Therefore, we propose FLAVOmega β as food supplement suitable for preventing muscle weakness, delaying inflammatory milieu, and sustaining physical health in patients affected from DMD.
Duchenne muscular dystrophy; Food supplement; Inflammatory response; Muscle homeostasis; Muscle regeneration; Satellite cells; Animals; Autophagy; Cardiomyopathy, Dilated; Cell Line; Cell Proliferation; Disease Models, Animal; Down-Regulation; Fatty Acids, Omega-3; Fibrosis; Flavonoids; Inflammation; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myoblasts; Myocardium; Oxidative Phosphorylation; Phenotype; Reactive Oxygen Species; Regeneration
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/905361
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