Background: sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation. Rehabilitation protocols for sarcopenia are designed to improve physical conditions, but very scarce data are available on their effects on inflammation We verified whether in sarcopenic patients the inflammation is reduced by rehabilitation and investigated the biological correlates of such effect. Methods: Twenty-one sarcopenic patients undergoing a specifically-designed rehabilitation program were enrolled in the study. Physical, cognitive and nutritional parameters, as well as the concentration of C-Reactive Protein (CRP), pro-and anti-inflammatory cytokines and cytokine production-modulating miRNAs were measured at the beginning (T0) and at end (30-days; T1) of the rehabilitation. Results: Rehabilitation resulted in a significant improvement of physical and cognitive conditions; this was accompanied by a significant reduction of CRP (p = 0.04) as well as of IL-18 (p = 0.008) and IL-37 (p = 0.009) concentration. Notably, the concentration of miR-335-3p (p = 0.007) and miR-657, the two known post-transcriptional regulators of IL-37 production, was increased by the rehabilitation protocol. Conclusions: Results herein confirm that successful rehabilitation for sarcopenia results in a reduction of the inflammatory milieu, raise the possibility that IL-37 may be a key target to monitor the rehabilitation-associated improvement in sarcopenia, and suggest that this cytokine could be a therapeutic target in sarcopenic patients.

Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation / F. La Rosa, S. Agostini, M. Saresella, A.S. Costa, F. Piancone, R. Miglioli, F. Trecate, M. Clerici. - In: JOURNAL OF TRANSLATIONAL MEDICINE. - ISSN 1479-5876. - 19:1(2021 Apr 26), pp. 172.1-172.8. [10.1186/s12967-021-02830-5]

Deregulation of IL-37 and its miRNAs modulators in sarcopenic patients after rehabilitation

F. La Rosa
Primo
;
A.S. Costa;F. Piancone;R. Miglioli;M. Clerici
Ultimo
2021-04-26

Abstract

Background: sarcopenia is a highly prevalent condition in elderly individuals which is characterized by loss of muscle mass and functions; recent results showed that it is also associated with inflammation. Rehabilitation protocols for sarcopenia are designed to improve physical conditions, but very scarce data are available on their effects on inflammation We verified whether in sarcopenic patients the inflammation is reduced by rehabilitation and investigated the biological correlates of such effect. Methods: Twenty-one sarcopenic patients undergoing a specifically-designed rehabilitation program were enrolled in the study. Physical, cognitive and nutritional parameters, as well as the concentration of C-Reactive Protein (CRP), pro-and anti-inflammatory cytokines and cytokine production-modulating miRNAs were measured at the beginning (T0) and at end (30-days; T1) of the rehabilitation. Results: Rehabilitation resulted in a significant improvement of physical and cognitive conditions; this was accompanied by a significant reduction of CRP (p = 0.04) as well as of IL-18 (p = 0.008) and IL-37 (p = 0.009) concentration. Notably, the concentration of miR-335-3p (p = 0.007) and miR-657, the two known post-transcriptional regulators of IL-37 production, was increased by the rehabilitation protocol. Conclusions: Results herein confirm that successful rehabilitation for sarcopenia results in a reduction of the inflammatory milieu, raise the possibility that IL-37 may be a key target to monitor the rehabilitation-associated improvement in sarcopenia, and suggest that this cytokine could be a therapeutic target in sarcopenic patients.
Cytokines; IL-37; Inflammaging; MiRNAs; Rehabilitation; Sarcopenia; Aged; C-Reactive Protein; Cytokines; Humans; Inflammation; Interleukin-1; MicroRNAs; Sarcopenia
Settore MED/04 - Patologia Generale
Settore MED/26 - Neurologia
CAR_RIC18CGELF_01 - Increased sarcopenia in a cohort of elderly carrying snap25 polymorphisms: mechanistic insights from the SNAP25 heterozygous murine model - GELFI, CECILIA - CAR_RIC - Bandi Fondazione Cariplo - 2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/905203
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