Objective: The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes of tumor spread in oral cavity tumors. Aim of the study was to investigate the impact of T-N tract involvement on the postoperative radiotherapy (PORT) outcomes. Materials and Methods: Patients (pts) treated between 2000 and 2016 with indication to PORT were retrospectively retrieved. Inclusion criteria were: (a) locally advanced tumors of the oral cavity, (b) who received with indication to PORT (c) with a minimum follow-up of six months. Results: One hundred and fifty-seven pts met the inclusion criteria (136 pts treated with PORT and 21 pts not treated with PORT). In the PORT cohort, the T-N tract involvement had no impact on both OS (p =.09) and LRFS (p =.2). Among the non-PORT cohort, both OS (p =.007) and LRFS (p =.017) were worse for pts with positive T-N tract compared to those with negative T-N tract. PORT improved both OS (p =.008) and LRFS (p =.003) in pts with positive T-N tract but not in those with negative T-N tract (p =.36 and p =.37, respectively). Conclusions: Our results suggest that involvement of T-N tract should be considered as prognostic factors informing the indication to PORT.

The T-N tract involvement as a new prognostic factor for PORT in locally advanced oral cavity tumors / D. Alterio, M. Augugliaro, M. Tagliabue, R. Bruschini, S. Gandini, L. Calabrese, P. Belloni, L. Preda, F.A. Maffini, G. Marvaso, A. Ferrari, S. Volpe, M.A. Zerella, O. Oneta, I. Turturici, O. Alessandro, F. Ruju, M. Ansarin, R. Orecchia, B.A. Jereczek-Fossa. - In: ORAL DISEASES. - ISSN 1354-523X. - (2021), pp. 1-10. [Epub ahead of print] [10.1111/odi.13885]

The T-N tract involvement as a new prognostic factor for PORT in locally advanced oral cavity tumors

Augugliaro M.;Tagliabue M.;Gandini S.;Marvaso G.;Ferrari A.;Volpe S.;Zerella M. A.;Oneta O.;Alessandro O.;Ruju F.;Orecchia R.;Jereczek-Fossa B. A.
2021

Abstract

Objective: The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes of tumor spread in oral cavity tumors. Aim of the study was to investigate the impact of T-N tract involvement on the postoperative radiotherapy (PORT) outcomes. Materials and Methods: Patients (pts) treated between 2000 and 2016 with indication to PORT were retrospectively retrieved. Inclusion criteria were: (a) locally advanced tumors of the oral cavity, (b) who received with indication to PORT (c) with a minimum follow-up of six months. Results: One hundred and fifty-seven pts met the inclusion criteria (136 pts treated with PORT and 21 pts not treated with PORT). In the PORT cohort, the T-N tract involvement had no impact on both OS (p =.09) and LRFS (p =.2). Among the non-PORT cohort, both OS (p =.007) and LRFS (p =.017) were worse for pts with positive T-N tract compared to those with negative T-N tract. PORT improved both OS (p =.008) and LRFS (p =.003) in pts with positive T-N tract but not in those with negative T-N tract (p =.36 and p =.37, respectively). Conclusions: Our results suggest that involvement of T-N tract should be considered as prognostic factors informing the indication to PORT.
oral cavity cancers; postoperative radiotherapy; T-N tract
Settore MED/36 - Diagnostica per Immagini e Radioterapia
24-apr-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/904003
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