Background: Radio-chemotherapy with CDDP is the standard for H&N squamous cell cancer. CDDP 100 mg/m2/q3 is the standard; alternative schedules are used to reduce toxicity, mostly 40 mg/m2/q1. Methods: Patients were treated from 1/2010 to 1/2017 in two Radiation Oncology Centres. Propensity score analysis (PS) was retrospectively used to compare these two schedules. Results: Patients analyzed were 166. Most (114/166) had 1w-CDDP while 52 had 3w-CDDP. In the 3w-CDDP group, patients were younger, with better performance status, smaller disease extent and a more common nodal involvement than in the 1w-CDDP. Acute toxicity was similar in the groups. Treatment compliance was lower in the w-CCDP. Overall survival before PS was better for female, for oropharyngeal disease and for 3w-CDDP group. After PS, survival was not related to the CDDP schedule. Conclusions: 3w-CDDP remains the standard for fit patients, weekly schedule could be safely used in selected patients.

Three weekly versus weekly concurrent cisplatin: safety propensity score analysis on 166 head and neck cancer patients / M. Buglione, D. Alterio, M. Maddalo, D. Greco, M.A. Gerardi, D. Tomasini, L. Pegurri, M. Augugliaro, G. Marvaso, I. Turturici, A. Guerini, M. Ansarin, L. Spiazzi, L. Costa, M. Cossu Rocca, S.M. Magrini, B.A. Jereczek-Fossa. - In: RADIATION ONCOLOGY. - ISSN 1748-717X. - 16:1(2021), pp. 239.1-239.13. [10.1186/s13014-021-01966-4]

Three weekly versus weekly concurrent cisplatin: safety propensity score analysis on 166 head and neck cancer patients

M. Maddalo;M.A. Gerardi;M. Augugliaro;G. Marvaso;L. Costa;B.A. Jereczek-Fossa
Ultimo
2021

Abstract

Background: Radio-chemotherapy with CDDP is the standard for H&N squamous cell cancer. CDDP 100 mg/m2/q3 is the standard; alternative schedules are used to reduce toxicity, mostly 40 mg/m2/q1. Methods: Patients were treated from 1/2010 to 1/2017 in two Radiation Oncology Centres. Propensity score analysis (PS) was retrospectively used to compare these two schedules. Results: Patients analyzed were 166. Most (114/166) had 1w-CDDP while 52 had 3w-CDDP. In the 3w-CDDP group, patients were younger, with better performance status, smaller disease extent and a more common nodal involvement than in the 1w-CDDP. Acute toxicity was similar in the groups. Treatment compliance was lower in the w-CCDP. Overall survival before PS was better for female, for oropharyngeal disease and for 3w-CDDP group. After PS, survival was not related to the CDDP schedule. Conclusions: 3w-CDDP remains the standard for fit patients, weekly schedule could be safely used in selected patients.
3weekly-CDDP; Chemotherapy; H&N cancer; Radiotherapy; Weekly-CDDP
Settore MED/36 - Diagnostica per Immagini e Radioterapia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/903947
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