Background and Aims: The disease course of microscopic colitis [MC] is considered chronic but benign. However, this assumption is based on mainly retrospective studies, reporting on incomplete follow-up of selective cohorts. Systematic, prospective and unbiased data to inform patients and healthcare professionals on the expected course of the disease and real-life response to therapy are warranted. Methods: A prospective, pan-European, multi-centre, web-based registry was established. Incident cases of MC were included. Data on patient characteristics, symptoms, treatment and quality of life were systematically registered at baseline and during real-time follow-up. Four disease course phenotypes were discriminated and described. Results: Among 381 cases with complete 1-year follow-up, 49% had a chronic active or relapsing disease course, 40% achieved sustained remission after treatment and 11% had a quiescent course. In general, symptoms and quality of life improved after 3 months of follow-up. A relapsing or chronic active disease course was associated with significantly more symptoms and impaired quality of life after 1 year. Conclusions: A minority of MC patients follow a quiescent disease course with spontaneous clinical improvement, whereas the majority suffer a chronic active or relapsing disease course during the first year after diagnosis, with persisting symptoms accompanied by a significantly impaired quality of life.
Course of Disease in Patients with Microscopic Colitis: A European Prospective Incident Cohort Study / B.P.M. Verhaegh, A. Munch, D. Guagnozzi, S. Wildt, W. Cebula, A.R. Diac, F. Fernandez-Banares, M.A.R. Al-Khalaf, N. Pedersen, J. Kupcinskas, J. Bohr, G. Macaigne, A.J. Lucendo, I. Lyutakov, G.E. Tontini, F. Pigo, E. Russo, H. Hjortswang, S. Miehlke, L.K. Munck. - In: JOURNAL OF CROHN'S AND COLITIS. - ISSN 1873-9946. - 15:7(2021 Jul 05), pp. 1174-1183. [10.1093/ecco-jcc/jjab007]
Course of Disease in Patients with Microscopic Colitis: A European Prospective Incident Cohort Study
G.E. Tontini;
2021
Abstract
Background and Aims: The disease course of microscopic colitis [MC] is considered chronic but benign. However, this assumption is based on mainly retrospective studies, reporting on incomplete follow-up of selective cohorts. Systematic, prospective and unbiased data to inform patients and healthcare professionals on the expected course of the disease and real-life response to therapy are warranted. Methods: A prospective, pan-European, multi-centre, web-based registry was established. Incident cases of MC were included. Data on patient characteristics, symptoms, treatment and quality of life were systematically registered at baseline and during real-time follow-up. Four disease course phenotypes were discriminated and described. Results: Among 381 cases with complete 1-year follow-up, 49% had a chronic active or relapsing disease course, 40% achieved sustained remission after treatment and 11% had a quiescent course. In general, symptoms and quality of life improved after 3 months of follow-up. A relapsing or chronic active disease course was associated with significantly more symptoms and impaired quality of life after 1 year. Conclusions: A minority of MC patients follow a quiescent disease course with spontaneous clinical improvement, whereas the majority suffer a chronic active or relapsing disease course during the first year after diagnosis, with persisting symptoms accompanied by a significantly impaired quality of life.File | Dimensione | Formato | |
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Verhaegh. Pro-MC at one year. JCC 2021.pdf
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